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Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, sporulation proteins, Transcription factors activating transcription at SigL-dependent promoters

This gene is a member of the following regulons

CcpA regulon

The AcoR regulon


  • Coordinates on the chromosome (coding sequence): 883,758 -> 885,575
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • Transcription factors activating transcription at SigL-dependent promoters
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity




    Additional information

    Expression and Regulation


  • acoR-sspH PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • repressed by glucose (3.7-fold) (CcpA) PubMed
  • Regulatory mechanism

  • CcpA: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-C352 (acoR::erm), available at the NBRP B. subtilis, Japan
  • 1A912 ( acoR::kan), PubMed, available at BGSC and in Jörg Stülke's lab
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein

  • Michel Debarbouille, Pasteur Institute, Paris, France Homepage
  • References

    Marciniak BC, Pabijaniak M, de Jong A, Dűhring R, Seidel G, Hillen W, Kuipers OP

    High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis

    BMC Genomics. 2012 Aug 17;13:401. doi: 10.1186/1471-2164-13-401. PubMed PMID: 22900538; PubMed Central PMCID: PMC3463425.
    Joly N, Zhang N, Buck M, Zhang X

    Coupling AAA protein function to regulated gene expression

    Biochim Biophys Acta. 2012 Jan;1823(1):108-16. doi: 10.1016/j.bbamcr.2011.08.012. Epub 2011 Aug 31. Review. PubMed PMID: 21906631.
    Blencke HM, Homuth G, Ludwig H, Mäder U, Hecker M, Stülke J

    Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways

    Metab Eng. 2003 Apr;5(2):133-49. PubMed PMID: 12850135.
    Ali NO, Bignon J, Rapoport G, Debarbouille M

    Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis

    J Bacteriol. 2001 Apr;183(8):2497-504. PubMed PMID: 11274109; PubMed Central PMCID: PMC95166.
    Huang M, Oppermann-Sanio FB, Steinbüchel A

    Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway

    J Bacteriol. 1999 Jun;181(12):3837-41. PubMed PMID: 10368162; PubMed Central PMCID: PMC93865.
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