SubtiBank SubtiBank
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Categories containing this gene/protein


transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons


AseR regulon

The AseR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 579,541 -> 579,876
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

  • ArsR family
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

  • As(III) acts as molecular inducer PubMed
  • Structure

    Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

    Sigma factor

    Regulation

  • induced by As(III) (AseR) PubMed
  • Regulatory mechanism

  • AseR: transcription repression (autorepression) PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-C168 (ydeT::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Harvie DR, Andreini C, Cavallaro G, Meng W, Connolly BA, Yoshida K, Fujita Y, Harwood CR, Radford DS, Tottey S, Cavet JS, Robinson NJ

    Predicting metals sensed by ArsR-SmtB repressors: allosteric interference by a non-effector metal

    Mol Microbiol. 2006 Feb;59(4):1341-56. PubMed PMID: 16430705.
    Moore CM, Gaballa A, Hui M, Ye RW, Helmann JD

    Genetic and physiological responses of Bacillus subtilis to metal ion stress

    Mol Microbiol. 2005 Jul;57(1):27-40. PubMed PMID: 15948947.
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