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Categories containing this gene/protein

utilization of amino acids, transcription factors and their control, Transcription factors activating transcription at SigL-dependent promoters

This gene is a member of the following regulons

CodY regulon

The BkdR regulon


  • Coordinates on the chromosome (coding sequence): 2,504,789 -> 2,506,867
  • Phenotypes of a mutant

  • The mutant is cold-sensitive PubMed
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • Transcription factors activating transcription at SigL-dependent promoters
  • Paralogous protein(s)

    Kinetic information


  • PAS domain
  • Modification


    Effectors of protein activity




  • BkdR-SigL (activation)
  • Additional information

    Expression and Regulation


  • bkdR PubMed
  • Sigma factor


  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism

  • CodY: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-C375 (yqiR::erm), available at the NBRP B. subtilis, Japan
  • 1A913 ( bkdR::kan), PubMed, available at BGSC and in Jörg Stülke's lab
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Traag BA, Pugliese A, Eisen JA, Losick R

    Gene conservation among endospore-forming bacteria reveals additional sporulation genes in Bacillus subtilis

    J Bacteriol. 2013 Jan;195(2):253-60. doi: 10.1128/JB.01778-12. Epub 2012 Nov 2. PubMed PMID: 23123912; PubMed Central PMCID: PMC3553846.
    Joly N, Zhang N, Buck M, Zhang X

    Coupling AAA protein function to regulated gene expression

    Biochim Biophys Acta. 2012 Jan;1823(1):108-16. doi: 10.1016/j.bbamcr.2011.08.012. Epub 2011 Aug 31. Review. PubMed PMID: 21906631.
    Wiegeshoff F, Beckering CL, Debarbouille M, Marahiel MA

    Sigma L is important for cold shock adaptation of Bacillus subtilis

    J Bacteriol. 2006 Apr;188(8):3130-3. PubMed PMID: 16585774; PubMed Central PMCID: PMC1446980.
    Yoshida K, Yamaguchi H, Kinehara M, Ohki YH, Nakaura Y, Fujita Y

    Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box

    Mol Microbiol. 2003 Jul;49(1):157-65. PubMed PMID: 12823818.
    Debarbouille M, Gardan R, Arnaud M, Rapoport G

    Role of bkdR, a transcriptional activator of the sigL-dependent isoleucine and valine degradation pathway in Bacillus subtilis

    J Bacteriol. 1999 Apr;181(7):2059-66. PubMed PMID: 10094682; PubMed Central PMCID: PMC93617.
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