SubtiBank SubtiBank

Categories containing this gene/protein


This gene is a member of the following regulons

CodY regulon


  • Coordinates on the chromosome (coding sequence): 1,688,676 -> 1,690,079
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • HslU subfamily (according to Swiss-Prot)
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity




  • ClpQ-ClpY PubMed
  • Additional information

    Expression and Regulation


  • codV-clpQ-clpY-codY PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism

  • CodY: transcription repression PubMed
  • Additional information

    Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Olivares AO, Baker TA, Sauer RT

    Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

    Nat Rev Microbiol. 2016 Jan;14(1):33-44. doi: 10.1038/nrmicro.2015.4. Epub 2015 Dec 7. Review. PubMed PMID: 26639779.
    Molière N, Turgay K

    General and regulatory proteolysis in Bacillus subtilis

    Subcell Biochem. 2013;66:73-103. doi: 10.1007/978-94-007-5940-4_4. Review. PubMed PMID: 23479438.

    Original publications

    Kang MS, Kim SR, Kwack P, Lim BK, Ahn SW, Rho YM, Seong IS, Park SC, Eom SH, Cheong GW, Chung CH

    Molecular architecture of the ATP-dependent CodWX protease having an N-terminal serine active site

    EMBO J. 2003 Jun 16;22(12):2893-902. PubMed PMID: 12805205; PubMed Central PMCID: PMC162141.
    Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL

    Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels

    Genes Dev. 2001 May 1;15(9):1093-103. PubMed PMID: 11331605; PubMed Central PMCID: PMC312684.
    Kang MS, Lim BK, Seong IS, Seol JH, Tanahashi N, Tanaka K, Chung CH

    The ATP-dependent CodWX (HslVU) protease in Bacillus subtilis is an N-terminal serine protease

    EMBO J. 2001 Feb 15;20(4):734-42. PubMed PMID: 11179218; PubMed Central PMCID: PMC145431.
    Slack FJ, Serror P, Joyce E, Sonenshein AL

    A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon

    Mol Microbiol. 1995 Feb;15(4):689-702. PubMed PMID: 7783641.
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