SubtiBank SubtiBank
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Categories containing this gene/protein


trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons


The CsoR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 3,443,896 -> 3,444,201
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

  • Cu(I) ions cause release of CsoR from its operator sites
  • Structure

    Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

    Sigma factor

    Regulation

    Regulatory mechanism

    Additional information

    Biological materials


    Mutant

  • MGNA-B604 (yvgZ::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


  • John Helmann, Cornell University, USA Homepage
  • Mohamed Marahiel, Marburg University, Germany homepage
  • References


    Reviews

    Hirooka K

    Transcriptional response machineries of Bacillus subtilis conducive to plant growth promotion

    Biosci Biotechnol Biochem. 2014;78(9):1471-84. doi: 10.1080/09168451.2014.943689. PubMed PMID: 25209494.
    Rademacher C, Masepohl B

    Copper-responsive gene regulation in bacteria

    Microbiology. 2012 Oct;158(Pt 10):2451-64. Review. PubMed PMID: 22918892.

    Original publications

    Chillappagari S, Seubert A, Trip H, Kuipers OP, Marahiel MA, Miethke M

    Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis

    J Bacteriol. 2010 May;192(10):2512-24. doi: 10.1128/JB.00058-10. PubMed PMID: 20233928; PubMed Central PMCID: PMC2863568.
    Ma Z, Cowart DM, Scott RA, Giedroc DP

    Molecular insights into the metal selectivity of the copper(I)-sensing repressor CsoR from Bacillus subtilis

    Biochemistry. 2009 Apr 21;48(15):3325-34. doi: 10.1021/bi900115w. PubMed PMID: 19249860; PubMed Central PMCID: PMC2728441.
    Chillappagari S, Miethke M, Trip H, Kuipers OP, Marahiel MA

    Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis

    J Bacteriol. 2009 Apr;191(7):2362-70. doi: 10.1128/JB.01616-08. PubMed PMID: 19168619; PubMed Central PMCID: PMC2655523.
    Chillappagari S, Miethke M, Trip H, Kuipers OP, Marahiel MA

    Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis

    J Bacteriol. 2009 Apr;191(7):2362-70. doi: 10.1128/JB.01616-08. PubMed PMID: 19168619; PubMed Central PMCID: PMC2655523.
    Smaldone GT, Helmann JD

    CsoR regulates the copper efflux operon copZA in Bacillus subtilis

    Microbiology. 2007 Dec;153(Pt 12):4123-8. PubMed PMID: 18048925; PubMed Central PMCID: PMC3019219.
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