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Categories containing this gene/protein


transcription factors and their control, heat shock proteins, phosphoproteins

This gene is a member of the following regulons


CssR regulon

The CssR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 3,385,724 -> 3,386,401
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

  • OmpR family of two-component response regulators
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

  • phosphorylated by CssS on an Asp residue
  • Cofactors

    Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity
  • Structure

    Localization

  • cytoplasm (according to Swiss-Prot)
  • Interactions

  • CssR interacts with the RNA polymerase PubMed
  • CssS-CssR
  • Additional information

    Expression and Regulation


    Operon

  • cssR-cssS PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • expressed under conditions of secretion stress (CssR) PubMed
  • Regulatory mechanism

  • CssR: transcription activation PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-B031 (yvqA::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Reviews

    Schumann W(1).

    Regulation of bacterial heat shock stimulons.

    Cell Stress Chaperones. 2016 Nov;21(6):959-968. Epub 2016 Aug 12.

    Original Publications

    Delumeau O, Lecointe F, Muntel J, Guillot A, Guédon E, Monnet V, Hecker M, Becher D, Polard P, Noirot P

    The dynamic protein partnership of RNA polymerase in Bacillus subtilis

    Proteomics. 2011 Aug;11(15):2992-3001. doi: 10.1002/pmic.201000790. Epub 2011 Jun 28. PubMed PMID: 21710567.
    Trip H, van der Veek PJ, Renniers TC, Meima R, Sagt CM, Mohrmann L, Kuipers OP

    A novel screening system for secretion of heterologous proteins in Bacillus subtilis

    Microb Biotechnol. 2011 Sep;4(5):673-82. doi: 10.1111/j.1751-7915.2011.00270.x. Epub 2011 May 30. PubMed PMID: 21624103; PubMed Central PMCID: PMC3819016.
    Kashyap DR, Wang M, Liu LH, Boons GJ, Gupta D, Dziarski R

    Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems

    Nat Med. 2011 Jun;17(6):676-83. doi: 10.1038/nm.2357. Epub 2011 May 22. PubMed PMID: 21602801; PubMed Central PMCID: PMC3176504.
    Zweers JC, Wiegert T, van Dijl JM

    Stress-responsive systems set specific limits to the overproduction of membrane proteins in Bacillus subtilis

    Appl Environ Microbiol. 2009 Dec;75(23):7356-64. doi: 10.1128/AEM.01560-09. Epub 2009 Oct 9. PubMed PMID: 19820159; PubMed Central PMCID: PMC2786430.
    Hyyryläinen HL, Pietiäinen M, Lundén T, Ekman A, Gardemeister M, Murtomäki-Repo S, Antelmann H, Hecker M, Valmu L, Sarvas M, Kontinen VP

    The density of negative charge in the cell wall influences two-component signal transduction in Bacillus subtilis

    Microbiology. 2007 Jul;153(Pt 7):2126-36. PubMed PMID: 17600057.
    Darmon E, Dorenbos R, Meens J, Freudl R, Antelmann H, Hecker M, Kuipers OP, Bron S, Quax WJ, Dubois JY, van Dijl JM

    A disulfide bond-containing alkaline phosphatase triggers a BdbC-dependent secretion stress response in Bacillus subtilis

    Appl Environ Microbiol. 2006 Nov;72(11):6876-85. PubMed PMID: 17088376; PubMed Central PMCID: PMC1636209.
    Darmon E, Noone D, Masson A, Bron S, Kuipers OP, Devine KM, van Dijl JM

    A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis

    J Bacteriol. 2002 Oct;184(20):5661-71. PubMed PMID: 12270824; PubMed Central PMCID: PMC139597.
    Darmon E, Noone D, Masson A, Bron S, Kuipers OP, Devine KM, van Dijl JM

    A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis

    J Bacteriol. 2002 Oct;184(20):5661-71. PubMed PMID: 12270824; PubMed Central PMCID: PMC139597.
    Hyyryläinen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Prágai Z, Bron S, van Dijl JM, Kontinen VP

    A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress

    Mol Microbiol. 2001 Sep;41(5):1159-72. PubMed PMID: 11555295.
    Fabret C, Feher VA, Hoch JA

    Two-component signal transduction in Bacillus subtilis: how one organism sees its world

    J Bacteriol. 1999 Apr;181(7):1975-83. Review. PubMed PMID: 10094672; PubMed Central PMCID: PMC93607.
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