cssR
168
two-component response regulator ([wiki|OmpR family]), control of cellular responses to [wiki|protein secretion] stress
locus
BSU_33010
Molecular weight
26.06 kDa
pI
5.07
function
control of cellular responses to protein secretion stress
product
two-component response regulator ([wiki|OmpR family])
essential
no
synonyms
cssR, yvqA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,385,724 3,386,401
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The protein
Protein family
[wiki|OmpR family] of two-component response regulators
[wiki|Domains]
[wiki|Response regulatory domain] (aa 4-117) (according to UniProt)
Structure
[PDB|2OQR] (from Mycobacterium tuberculosis, 34% identity)
[AF|O32192]
Modification
phosphorylated by [protein|4EE48E4931F662E51586DB6D01E91C688329222D|cssS] on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]-[gene|4EE48E4931F662E51586DB6D01E91C688329222D|cssS]
description
[Pubmed|11555295]
regulation
expressed under conditions of secretion stress ([protein|search|CssR]) [Pubmed|12270824]
regulatory mechanism
[protein|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]: activation, [Pubmed|12270824], in [regulon|protein:A40CD2C23A19860342F440284302EFFDAC09E88A|cssR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|12270824], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
Biological materials
Mutant
MGNA-B031 (yvqA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1030 NBRP B. subtilis, Japan]
BKE33010 ([gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC
BKK33010 ([gene|A40CD2C23A19860342F440284302EFFDAC09E88A|cssR]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33010 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGGCTCTTCACATCCTTT, downstream forward: _UP4_TTCGGCTACAGGATGATGTC
References
Reviews
Original Publications
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Time of last update: 2024-04-17 10:23:17
Author of last update: Jstuelk