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Categories containing this gene/protein


utilization of nucleotides, transcription factors and their control

This gene is a member of the following regulons


The DeoR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 4,052,379 -> 4,053,320
  • The protein


    Catalyzed reaction/ biological activity

  • transcription repression of the dra-nupC-pdp operon
  • Protein family

  • sorC transcriptional regulatory family (according to Swiss-Prot) DeoR family of transcription repressors
  • Paralogous protein(s)

    Kinetic information

    Domains

  • N-terminal DNA-binding domain PubMed
  • C-terminal effector binding domain PubMed
  • Modification

    Cofactors

    Effectors of protein activity

  • deoxyribose-5-phosphate acts as the molecular inducer PubMed
  • Structure

  • 4OQQ (C-terminal effector binding domain) PubMed
  • 4OQP (C-terminal effector binding domain bound to the effector deoxyribose-5-phosphate ) PubMed
  • Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

  • deoR PubMed
  • Sigma factor

    Regulation

    Regulatory mechanism

    Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Škerlová J, Fábry M, Hubálek M, Otwinowski Z, Rezáčová P

    Structure of the effector-binding domain of deoxyribonucleoside regulator DeoR from Bacillus subtilis

    FEBS J. 2014 Sep;281(18):4280-92. doi: 10.1111/febs.12856. Epub 2014 Jun 25. PubMed PMID: 24863636.
    Zeng X, Saxild HH, Switzer RL

    Purification and characterization of the DeoR repressor of Bacillus subtilis

    J Bacteriol. 2000 Apr;182(7):1916-22. PubMed PMID: 10714997; PubMed Central PMCID: PMC101877.
    Zeng X, Saxild HH

    Identification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis

    J Bacteriol. 1999 Mar;181(6):1719-27. PubMed PMID: 10074062; PubMed Central PMCID: PMC93568.
    Saxild HH, Andersen LN, Hammer K

    Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein

    J Bacteriol. 1996 Jan;178(2):424-34. PubMed PMID: 8550462; PubMed Central PMCID: PMC177674.
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