SubtiBank SubtiBank

It will happen very soon:

International Conference on Bacilli and Gram-positive bacteria

June 11 - 15, 2017, Berlin, Germany

Check out the program here

'

Categories containing this gene/protein


utilization of specific carbon sources, transcription factors and their control, sporulation proteins

This gene is a member of the following regulons


CcpA regulon, ExuR regulon, SigE regulon

The ExuR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 1,308,802 -> 1,309,803
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

  • LacI family
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

  • galacturonate acts as the molecular inducer PubMed
  • Structure

    Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

  • uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed
  • yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed
  • Sigma factor

  • SigE PubMed
  • uxaC: SigA PubMed
  • yjmC: SigE PubMed
  • Regulation

  • repressed by glucose (CcpA) PubMed1 PubMed2
  • induced by galacturonate (ExuR) PubMed
  • Regulatory mechanism

  • CcpA: transcription repression PubMed1 PubMed2
  • ExuR: reanscription repression in the absence of inducer PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-A372 (yjmH::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Miwa Y, Nakata A, Ogiwara A, Yamamoto M, Fujita Y

    Evaluation and characterization of catabolite-responsive elements (cre) of Bacillus subtilis

    Nucleic Acids Res. 2000 Mar 1;28(5):1206-10. PubMed PMID: 10666464; PubMed Central PMCID: PMC102602.
    Mekjian KR, Bryan EM, Beall BW, Moran CP Jr

    Regulation of hexuronate utilization in Bacillus subtilis

    J Bacteriol. 1999 Jan;181(2):426-33. PubMed PMID: 9882655; PubMed Central PMCID: PMC93395.
    Rivolta C, Soldo B, Lazarevic V, Joris B, Mauël C, Karamata D

    A 35

    7 kb DNA fragment from the Bacillus subtilis chromosome containing a putative 12.3 kb operon involved in hexuronate catabolism and a perfectly symmetrical hypothetical catabolite-responsive element. Microbiology. 1998 Apr;144 ( Pt 4):877-84. PubMed PMID: 9579062.
    '
    No login