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Categories containing this gene/protein


acquisition of iron, iron metabolism, RNA chaperones, short peptides

This gene is a member of the following regulons


Fur regulon

The FbpB regulon


Gene


  • Coordinates on the chromosome (coding sequence): 506,322 -> 506,501
  • Phenotypes of a mutant

  • transcription profile of a fbpA fbpB double mutant strain: GEO PubMed
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

    Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

  • fbpA-fbpB PubMed
  • Sigma factor

    Regulation

  • induced upon iron starvation (Fur) PubMed
  • Regulatory mechanism

  • Fur: transcription repression PubMed
  • Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Smaldone GT, Antelmann H, Gaballa A, Helmann JD

    The FsrA sRNA and FbpB protein mediate the iron-dependent induction of the Bacillus subtilis lutABC iron-sulfur-containing oxidases

    J Bacteriol. 2012 May;194(10):2586-93. doi: 10.1128/JB.05567-11. Epub 2012 Mar 16. PubMed PMID: 22427629; PubMed Central PMCID: PMC3347220.
    Smaldone GT, Revelles O, Gaballa A, Sauer U, Antelmann H, Helmann JD

    A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism

    J Bacteriol. 2012 May;194(10):2594-605. doi: 10.1128/JB.05990-11. Epub 2012 Mar 2. PubMed PMID: 22389480; PubMed Central PMCID: PMC3347201.
    Irnov I, Sharma CM, Vogel J, Winkler WC

    Identification of regulatory RNAs in Bacillus subtilis

    Nucleic Acids Res. 2010 Oct;38(19):6637-51. doi: 10.1093/nar/gkq454. Epub 2010 Jun 4. PubMed PMID: 20525796; PubMed Central PMCID: PMC2965217.
    Gaballa A, Antelmann H, Aguilar C, Khakh SK, Song KB, Smaldone GT, Helmann JD

    The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins

    Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11927-32. doi: 10.1073/pnas.0711752105. Epub 2008 Aug 12. PubMed PMID: 18697947; PubMed Central PMCID: PMC2575260.
    Baichoo N, Wang T, Ye R, Helmann JD

    Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon

    Mol Microbiol. 2002 Sep;45(6):1613-29. PubMed PMID: 12354229.
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