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Categories containing this gene/protein

miscellaneous metabolic pathways, transcription factors and their control, coping with hyper-osmotic stress

This gene is a member of the following regulons

The GbsR regulon


  • Coordinates on the chromosome (coding sequence): 3,186,763 -> 3,187,305
  • The protein

    Catalyzed reaction/ biological activity

  • sensing of choline PubMed
  • control of the gbsA-gbsB and opuBA-opuBB-opuBC-opuBD operons PubMed
  • Protein family

    Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • binds the inducer choline with an apparent K(D) of approximately 165 μM PubMed
  • Structure



    Additional information

    Expression and Regulation


    Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-A219 (yuaC::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein

  • Erhard Bremer, University of Marburg, Germany homepage
  • References

    Nau-Wagner G(1), Opper D, Rolbetzki A, Boch J, Kempf B, Hoffmann T, Bremer E.

    Genetic control of osmoadaptive glycine betaine synthesis in Bacillus subtilis through the choline-sensing and glycine betaine-responsive GbsR repressor.

    J Bacteriol. 2012 May;194(10):2703-14. doi: 10.1128/JB.06642-11. Epub 2012 Mar 9.
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