SubtiBank SubtiBank
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Categories containing this gene/protein


transcription factors and their control, sporulation proteins

This gene is a member of the following regulons


SigE regulon, SpoIIID regulon

The GerR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 1,576,129 -> 1,576,710
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

  • phosphorylated on Ser-180 PubMed
  • Cofactors

    Effectors of protein activity

    Structure

    Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

  • gerR (according to DBTBS)
  • Sigma factor

  • SigE PubMed
  • Regulation

  • expressed during sporulation in the mother cell (SigE, SpoIIID) PubMed
  • repressed by glucose (3.2-fold) PubMed
  • repressed by casamino acids PubMed
  • Regulatory mechanism

  • SpoIIID: transcription activation PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-B252 (ylbO::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Soufi B, Kumar C, Gnad F, Mann M, Mijakovic I, Macek B

    Stable isotope labeling by amino acids in cell culture (SILAC) applied to quantitative proteomics of Bacillus subtilis

    J Proteome Res. 2010 Jul 2;9(7):3638-46. doi: 10.1021/pr100150w. PubMed PMID: 20509597.
    Cangiano G, Mazzone A, Baccigalupi L, Isticato R, Eichenberger P, De Felice M, Ricca E

    Direct and indirect control of late sporulation genes by GerR of Bacillus subtilis

    J Bacteriol. 2010 Jul;192(13):3406-13. doi: 10.1128/JB.00329-10. PubMed PMID: 20435725; PubMed Central PMCID: PMC2897654.
    Kuwana R, Okumura T, Takamatsu H, Watabe K

    The ylbO gene product of Bacillus subtilis is involved in the coat development and lysozyme resistance of spore

    FEMS Microbiol Lett. 2005 Jan 1;242(1):51-7. PubMed PMID: 15621419.
    Eichenberger P, Fujita M, Jensen ST, Conlon EM, Rudner DZ, Wang ST, Ferguson C, Haga K, Sato T, Liu JS, Losick R

    The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis

    PLoS Biol. 2004 Oct;2(10):e328. PubMed PMID: 15383836; PubMed Central PMCID: PMC517825.
    Blencke HM, Homuth G, Ludwig H, Mäder U, Hecker M, Stülke J

    Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways

    Metab Eng. 2003 Apr;5(2):133-49. PubMed PMID: 12850135.
    Mäder U, Homuth G, Scharf C, Büttner K, Bode R, Hecker M

    Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability

    J Bacteriol. 2002 Aug;184(15):4288-95. PubMed PMID: 12107147; PubMed Central PMCID: PMC135197.
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