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Categories containing this gene/protein

utilization of specific carbon sources, utilization of lipids, transcription factors and their control, RNA binding regulators

This gene is a member of the following regulons

The GlpP regulon


  • Coordinates on the chromosome (coding sequence): 1,001,744 -> 1,002,322
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information




    Effectors of protein activity




    Additional information

    Expression and Regulation


  • yhxA-glpP PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

    Regulatory mechanism

    Additional information

  • half-life of the mRNA: 3.7 min PubMed
  • the mRNA is stabilized in rppH and rnjA mutants PubMed
  • the mRNA is subject to degradation by RNase J1 PubMed
  • Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein

  • Josef Deutscher, Paris-Grignon, France
  • References

    Richards J, Liu Q, Pellegrini O, Celesnik H, Yao S, Bechhofer DH, Condon C, Belasco JG

    An RNA pyrophosphohydrolase triggers 5'-exonucleolytic degradation of mRNA in Bacillus subtilis

    Mol Cell. 2011 Sep 16;43(6):940-9. doi: 10.1016/j.molcel.2011.07.023. PubMed PMID: 21925382; PubMed Central PMCID: PMC3176438.
    Darbon E, Servant P, Poncet S, Deutscher J

    Antitermination by GlpP, catabolite repression via CcpA and inducer exclusion triggered by P-GlpK dephosphorylation control Bacillus subtilis glpFK expression

    Mol Microbiol. 2002 Feb;43(4):1039-52. PubMed PMID: 11929549.
    Glatz E, Farewell A, Rutberg B

    The Bacillus subtilis glpD leader and antiterminator protein GlpP provide a target for glucose repression in Escherichia coli

    FEMS Microbiol Lett. 1998 May 1;162(1):93-6. PubMed PMID: 9595668.
    Glatz E, Persson M, Rutberg B

    Antiterminator protein GlpP of Bacillus subtilis binds to glpD leader mRNA

    Microbiology. 1998 Feb;144 ( Pt 2):449-56. PubMed PMID: 9493382.
    Glatz E, Nilsson RP, Rutberg L, Rutberg B

    A dual role for the Bacillus subtilis glpD leader and the GlpP protein in the regulated expression of glpD: antitermination and control of mRNA stability

    Mol Microbiol. 1996 Jan;19(2):319-28. PubMed PMID: 8825777.
    Beijer L, Nilsson RP, Holmberg C, Rutberg L

    The glpP and glpF genes of the glycerol regulon in Bacillus subtilis

    J Gen Microbiol. 1993 Feb;139(2):349-59. PubMed PMID: 8436953.
    Holmberg C, Rutberg B

    Expression of the gene encoding glycerol-3-phosphate dehydrogenase (glpD) in Bacillus subtilis is controlled by antitermination

    Mol Microbiol. 1991 Dec;5(12):2891-900. PubMed PMID: 1809833.
    Holmberg C, Rutberg L

    An inverted repeat preceding the Bacillus subtilis glpD gene is a conditional terminator of transcription

    Mol Microbiol. 1992 Oct;6(20):2931-8. PubMed PMID: 1479885.
    Lindgren V, Rutberg L

    Genetic control of the glp system in Bacillus subtilis

    J Bacteriol. 1976 Sep;127(3):1047-57. PubMed PMID: 182672; PubMed Central PMCID: PMC232894.
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