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Categories containing this gene/protein


utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons


AbrB regulon, CcpA regulon, GmuR regulon

The GmuR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 630,170 -> 630,883
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

  • GntR family of transcription factors
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

  • 2WV0 (the structure of NagR, 29% identity) PubMed
  • Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

  • gmuB-gmuA-gmuC-gmuD-gmuR-gmuE-gmuF-gmuG PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • induced by conjac glucomannan (requires GmuG) (GmuR) PubMed
  • induced by cellobiose (GmuR) PubMed
  • subject to carbon catabolite repression (CcpA) PubMed
  • Regulatory mechanism

  • GmuR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • AbrB: transcription activation PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-C192 (ydhQ::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Chumsakul O, Takahashi H, Oshima T, Hishimoto T, Kanaya S, Ogasawara N, Ishikawa S

    Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation

    Nucleic Acids Res. 2011 Jan;39(2):414-28. doi: 10.1093/nar/gkq780. Epub 2010 Sep 3. PubMed PMID: 20817675; PubMed Central PMCID: PMC3025583.
    Resch M, Schiltz E, Titgemeyer F, Muller YA

    Insight into the induction mechanism of the GntR/HutC bacterial transcription regulator YvoA

    Nucleic Acids Res. 2010 Apr;38(7):2485-97. doi: 10.1093/nar/gkp1191. Epub 2010 Jan 4. PubMed PMID: 20047956; PubMed Central PMCID: PMC2853113.
    Sadaie Y, Nakadate H, Fukui R, Yee LM, Asai K

    Glucomannan utilization operon of Bacillus subtilis

    FEMS Microbiol Lett. 2008 Feb;279(1):103-9. doi: 10.1111/j.1574-6968.2007.01018.x. PubMed PMID: 18177310.
    Sadaie Y, Nakadate H, Fukui R, Yee LM, Asai K

    Glucomannan utilization operon of Bacillus subtilis

    FEMS Microbiol Lett. 2008 Feb;279(1):103-9. doi: 10.1111/j.1574-6968.2007.01018.x. PubMed PMID: 18177310.
    Reizer J, Bachem S, Reizer A, Arnaud M, Saier MH Jr, Stülke J

    Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis

    Microbiology. 1999 Dec;145 ( Pt 12):3419-29. PubMed PMID: 10627040.
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