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Categories containing this gene/protein

utilization of amino acids, transcription factors and their control, RNA binding regulators

This gene is a member of the following regulons

CcpA regulon, CodY regulon

The HutP regulon


  • Coordinates on the chromosome (coding sequence): 4,041,483 -> 4,041,938
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • hutP family (according to Swiss-Prot)
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • HutP binds its RNA target to cause antitermination in the presence of histidine PubMed
  • Structure

  • 3BOY (complex bound to the hut mRNA), 1WPT
  • Localization


    Additional information

    Expression and Regulation


  • hutP-hutH-hutU-hutI-hutG-hutM PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • repressed by glucose (CcpA) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism

  • CcpA: transcription repression PubMed
  • CodY: transcription repression PubMed
  • Additional information

    Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Bender RA

    Regulation of the histidine utilization (hut) system in bacteria

    Microbiol Mol Biol Rev. 2012 Sep;76(3):565-84. doi: 10.1128/MMBR.00014-12. Review. PubMed PMID: 22933560; PubMed Central PMCID: PMC3429618.
    Kumarevel T

    Structural insights of HutP-mediated regulation of transcription of the hut operon in Bacillus subtilis

    Biophys Chem. 2007 Jun;128(1):1-12. Epub 2007 Mar 13. Review. PubMed PMID: 17395359.
    Kumar PK, Kumarevel T, Mizuno H

    Structural basis of HutP-mediated transcription anti-termination

    Curr Opin Struct Biol. 2006 Feb;16(1):18-26. Epub 2006 Jan 19. Review. PubMed PMID: 16427271.
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