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International Conference on Bacilli and Gram-positive bacteria
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Categories containing this gene/protein
utilization of amino acids, transcription factors and their control, RNA binding regulators
This gene is a member of the following regulons
CcpA regulon, CodY regulon
Coordinates on the chromosome (coding sequence): 4,041,483 -> 4,041,938
Catalyzed reaction/ biological activity
Protein familyhutP family (according to Swiss-Prot)
Effectors of protein activityHutP binds its RNA target to cause antitermination in the presence of histidine PubMed
Structure3BOY (complex bound to the hut mRNA), 1WPT
Expression and Regulation
OperonhutP-hutH-hutU-hutI-hutG-hutM PubMedSigA PubMed
Regulationrepressed by glucose (CcpA) PubMedrepressed during growth in the presence of branched chain amino acids (CodY) PubMed
Regulatory mechanismCcpA: transcription repression PubMedCodY: transcription repression PubMed
Labs working on this gene/protein
Regulation of the histidine utilization (hut) system in bacteria
Microbiol Mol Biol Rev. 2012 Sep;76(3):565-84. doi: 10.1128/MMBR.00014-12.
Review. PubMed PMID: 22933560; PubMed Central PMCID: PMC3429618.
Structural insights of HutP-mediated regulation of transcription
of the hut operon in Bacillus subtilis Biophys Chem. 2007 Jun;128(1):1-12. Epub
2007 Mar 13. Review. PubMed PMID: 17395359.
Kumar PK, Kumarevel T, Mizuno H
Structural basis of HutP-mediated
transcription anti-termination Curr Opin Struct Biol. 2006 Feb;16(1):18-26. Epub
2006 Jan 19. Review. PubMed PMID: 16427271.