SubtiBank SubtiBank

It will happen very soon:

International Conference on Bacilli and Gram-positive bacteria

June 11 - 15, 2017, Berlin, Germany

Check out the program here

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The HxlR regulon


  • Coordinates on the chromosome (coding sequence): 376,032 -> 376,394
  • The protein

    Catalyzed reaction/ biological activity

  • transcription activation of the ribulose monophosphate pathway for formaldehyde fixation and detoxification
  • Protein family

  • [[MarR/DUF24 family]]
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • formaldehyde stimulates transcription activation by HxlR
  • Structure



    Additional information

    Expression and Regulation


  • hxlR (according to DBTBS)
  • Sigma factor


    Regulatory mechanism

    Additional information

  • A ncRNA is predicted between hxlR and srfAA PubMed
  • Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Irnov I, Sharma CM, Vogel J, Winkler WC

    Identification of regulatory RNAs in Bacillus subtilis

    Nucleic Acids Res. 2010 Oct;38(19):6637-51. doi: 10.1093/nar/gkq454. Epub 2010 Jun 4. PubMed PMID: 20525796; PubMed Central PMCID: PMC2965217.
    Nguyen TT, Eiamphungporn W, Mäder U, Liebeke M, Lalk M, Hecker M, Helmann JD, Antelmann H

    Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR)

    Mol Microbiol. 2009 Feb;71(4):876-94. doi: 10.1111/j.1365-2958.2008.06568.x. Epub 2008 Dec 23. PubMed PMID: 19170879.
    Kato N, Yurimoto H, Thauer RK

    The physiological role of the ribulose monophosphate pathway in bacteria and archaea

    Biosci Biotechnol Biochem. 2006 Jan;70(1):10-21. Review. PubMed PMID: 16428816.
    Yasueda H, Kawahara Y, Sugimoto S

    Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression

    J Bacteriol. 1999 Dec;181(23):7154-60. PubMed PMID: 10572115; PubMed Central PMCID: PMC103674.
    No login