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Description: transcriptional repressor (Xre family), controls expression of genes of the mobile genetic element ICEBs1, induction by the SOS response or the RapI-PhrI sensory system

Name: immR
Locus: BSU04820BsubCyc
pI: 5.0
MW: 14.0 kDa
Protein length: 127 aaBLASTSequence
Gene length: 381 bpBLASTSequenceSequence + Flanks
Function: control of transfer of the mobile
genetic element ICEBs1
Product: transcriptional repressor (Xre family)
Essential: no
E.C. number:
Synonyms: ydcN
Databases: SubtiListKEGGUniProtExpression data browser

Categories containing this gene/protein

transcription factors and their control, mobile genetic elements

This gene is a member of the following regulons

The ImmR regulon


  • Coordinates on the chromosome (coding sequence): 531,130 -> 531,513
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • Xre family
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • binding of RapI to ImmR results in loss of DNA-binding activity of ImmR and subsequently in induction of ImmR-repressed genes PubMed
  • Structure



  • ImmA-ImmR PubMed
  • RapI-ImmR PubMed
  • Additional information

    Expression and Regulation


    Sigma factor


    Regulatory mechanism

    Additional information

  • ImmR is degraded by the anti-repressor ImmA PubMed
  • Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Singh PK(1), Meijer WJ.

    Diverse regulatory circuits for transfer of conjugative elements.

    FEMS Microbiol Lett. 2014 Sep;358(2):119-28. doi: 10.1111/1574-6968.12526. Epub 2014 Jul 17.DOI: 10.1111/1574-6968.12526 PMID: 24995588 [Indexed for MEDLINE]

    Original publications

    Bose B, Grossman AD

    Regulation of horizontal gene transfer in Bacillus subtilis by activation of a conserved site-specific protease

    J Bacteriol. 2011 Jan;193(1):22-9. doi: 10.1128/JB.01143-10. Epub 2010 Oct 29. PubMed PMID: 21036995; PubMed Central PMCID: PMC3019953.
    Bose B, Auchtung JM, Lee CA, Grossman AD

    A conserved anti-repressor controls horizontal gene transfer by proteolysis

    Mol Microbiol. 2008 Nov;70(3):570-82. doi: 10.1111/j.1365-2958.2008.06414.x. Epub 2008 Aug 29. PubMed PMID: 18761623; PubMed Central PMCID: PMC2581648.
    Auchtung JM, Lee CA, Garrison KL, Grossman AD

    Identification and characterization of the immunity repressor (ImmR) that controls the mobile genetic element ICEBs1 of Bacillus subtilis

    Mol Microbiol. 2007 Jun;64(6):1515-28. Epub 2007 May 18. PubMed PMID: 17511812; PubMed Central PMCID: PMC3320793.
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