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Categories containing this gene/protein


utilization of specific carbon sources, transcription factors and their control, sporulation/ other

This gene is a member of the following regulons


IolR regulon

The IolR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 4,084,799 -> 4,085,554
  • Phenotypes of a mutant

  • inactivation of iolR reduces sporulation efficiency to 38% that of wild type cells PubMed
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

  • inducer: 2-deoxy-5-keto-D-gluconic acid-6-phosphate
  • Structure

    Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

  • iolR-iolS PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • induced by inositol (IolR) PubMed
  • Regulatory mechanism

  • IolR: transcription repression PubMed
  • Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


  • Yasutaro Fujita, University of Fukuyama, Japan
  • [[Ken-ichi Yoshida]], Kobe University, Japan
  • References


    Meeske AJ, Rodrigues CD, Brady J, Lim HC, Bernhardt TG, Rudner DZ

    High-Throughput Genetic Screens Identify a Large and Diverse Collection of New Sporulation Genes in Bacillus subtilis

    PLoS Biol. 2016 Jan 6;14(1):e1002341. doi: 10.1371/journal.pbio.1002341. eCollection 2016 Jan. PubMed PMID: 26735940; PubMed Central PMCID: PMC4703394.
    Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y

    myo-Inositol catabolism in Bacillus subtilis

    J Biol Chem. 2008 Apr 18;283(16):10415-24. doi: 10.1074/jbc.M708043200. Epub 2008 Feb 28. PubMed PMID: 18310071.
    Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y

    myo-Inositol catabolism in Bacillus subtilis

    J Biol Chem. 2008 Apr 18;283(16):10415-24. doi: 10.1074/jbc.M708043200. Epub 2008 Feb 28. PubMed PMID: 18310071.
    Yoshida KI, Shibayama T, Aoyama D, Fujita Y

    Interaction of a repressor and its binding sites for regulation of the Bacillus subtilis iol divergon

    J Mol Biol. 1999 Jan 22;285(3):917-29. PubMed PMID: 9887260.
    Yoshida KI, Shibayama T, Aoyama D, Fujita Y

    Interaction of a repressor and its binding sites for regulation of the Bacillus subtilis iol divergon

    J Mol Biol. 1999 Jan 22;285(3):917-29. PubMed PMID: 9887260.
    Yoshida KI, Aoyama D, Ishio I, Shibayama T, Fujita Y

    Organization and transcription of the myo-inositol operon, iol, of Bacillus subtilis

    J Bacteriol. 1997 Jul;179(14):4591-8. PubMed PMID: 9226270; PubMed Central PMCID: PMC179296.
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