SubtiBank SubtiBank

It will happen very soon:

International Conference on Bacilli and Gram-positive bacteria

June 11 - 15, 2017, Berlin, Germany

Check out the program here


Categories containing this gene/protein

genetic competence

This gene is a member of the following regulons

ComK regulon

The Kre regulon


  • Coordinates on the chromosome (coding sequence): 1,474,560 -> 1,475,024
  • The protein

    Catalyzed reaction/ biological activity

  • stimulates ComK mRNA degradation PubMed
  • controls stability of several mRNAs (see Kre regulon) PubMed
  • Protein family

    Paralogous protein(s)

    Kinetic information




    Effectors of protein activity



  • cytoplasm PubMed
  • Interactions

    Additional information

    Expression and Regulation


  • kre PubMed
  • Sigma factor


  • repressed in competent cells (ComK) PubMed
  • Regulatory mechanism

  • ComK: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-A764 (ykyB::erm), available at the NBRP B. subtilis, Japan
  • PG479 (ykyB::erm), available in Leendert Hamoens and Jörg Stülkes labs PubMed
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Kampf J(1), Stülke J(1).

    Minor Cause--Major Effect: A Novel Mode of Control of Bistable Gene Expression.

    PLoS Genet. 2015 Jun 25;11(6):e1005229. doi: 10.1371/journal.pgen.1005229. eCollection 2015 Jun.

    Original Publications

    Gamba P, Jonker MJ, Hamoen LW

    A Novel Feedback Loop That Controls Bimodal Expression of Genetic Competence

    PLoS Genet. 2015 Jun 25;11(6):e1005047. doi: 10.1371/journal.pgen.1005047. eCollection 2015 Jun. PubMed PMID: 26110430; PubMed Central PMCID: PMC4482431.
    Fredrick KL, Helmann JD

    Dual chemotaxis signaling pathways in Bacillus subtilis: a sigma D-dependent gene encodes a novel protein with both CheW and CheY homologous domains

    J Bacteriol. 1994 May;176(9):2727-35. PubMed PMID: 8169223; PubMed Central PMCID: PMC205414.
    No login