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Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, phosphoproteins, Transcription factors activating transcription at SigL-dependent promoters

This gene is a member of the following regulons

The LevR regulon


  • Coordinates on the chromosome (coding sequence): 2,763,025 -> 2,765,832
  • The protein

    Catalyzed reaction/ biological activity

  • binding to the upstream activating sequence in front of the levD gene results in activation of transcription of the levD-levE-levF-levG-sacC operon, bining occurs in the presence of fructose
  • Protein family

  • Transcription factors activating transcription at SigL-dependent promoters
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity



  • cytoplasm (according to Swiss-Prot)
  • Interactions

  • PtsH-LevR
  • LevE-LevR
  • LevR-SigL
  • Additional information

    Expression and Regulation


    Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Joly N, Zhang N, Buck M, Zhang X

    Coupling AAA protein function to regulated gene expression

    Biochim Biophys Acta. 2012 Jan;1823(1):108-16. doi: 10.1016/j.bbamcr.2011.08.012. Epub 2011 Aug 31. Review. PubMed PMID: 21906631.
    Martin-Verstraete I, Charrier V, Stülke J, Galinier A, Erni B, Rapoport G, Deutscher J

    Antagonistic effects of dual PTS-catalysed phosphorylation on the Bacillus subtilis transcriptional activator LevR

    Mol Microbiol. 1998 Apr;28(2):293-303. PubMed PMID: 9622354.
    Charrier V, Deutscher J, Galinier A, Martin-Verstraete I

    Protein phosphorylation chain of a Bacillus subtilis fructose-specific phosphotransferase system and its participation in regulation of the expression of the lev operon

    Biochemistry. 1997 Feb 4;36(5):1163-72. PubMed PMID: 9033408.
    Martin-Verstraete I, Débarbouillé M, Klier A, Rapoport G

    Interactions of wild-type and truncated LevR of Bacillus subtilis with the upstream activating sequence of the levanase operon

    J Mol Biol. 1994 Aug 12;241(2):178-92. PubMed PMID: 8057358.
    Stülke J, Martin-Verstraete I, Charrier V, Klier A, Deutscher J, Rapoport G

    The HPr protein of the phosphotransferase system links induction and catabolite repression of the Bacillus subtilis levanase operon

    J Bacteriol. 1995 Dec;177(23):6928-36. PubMed PMID: 7592487; PubMed Central PMCID: PMC177562.
    Martin-Verstraete I, Stülke J, Klier A, Rapoport G

    Two different mechanisms mediate catabolite repression of the Bacillus subtilis levanase operon

    J Bacteriol. 1995 Dec;177(23):6919-27. PubMed PMID: 7592486; PubMed Central PMCID: PMC177561.
    Débarbouillé M, Martin-Verstraete I, Klier A, Rapoport G

    The transcriptional regulator LevR of Bacillus subtilis has domains homologous to both sigma 54- and phosphotransferase system-dependent regulators

    Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2212-6. PubMed PMID: 1900939; PubMed Central PMCID: PMC51200.
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