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Categories containing this gene/protein
transcription factors and their control, resistance against toxins/ antibiotics
This gene is a member of the following regulons
Coordinates on the chromosome (coding sequence): 290,132 -> 290,698
Catalyzed reaction/ biological activity
Protein familyTetR family
Effectors of protein activityflavonoids such as quercetin serve as inducers, binding results in release from DNA PubMed
Expression and Regulation
OperonlmrA-lmrB PubMedSigA PubMed
Regulationinduced by flavonoids such as quercetin (LmrA)PubMed
Regulatory mechanismLmrA: transcription repression PubMed
Additional informationthe mRNA is substantially stabilized upon depletion of RNase Y PubMed
Labs working on this gene/protein
Transcriptional response machineries of Bacillus subtilis conducive
to plant growth promotion Biosci Biotechnol Biochem. 2014;78(9):1471-84. doi:
10.1080/09168451.2014.943689. PubMed PMID: 25209494.
Cuthbertson L, Nodwell JR
The TetR family of regulators Microbiol Mol Biol
Rev. 2013 Sep;77(3):440-75. doi: 10.1128/MMBR.00018-13. Review. PubMed PMID:
24006471; PubMed Central PMCID: PMC3811609.
Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J
processing in Bacillus subtilis: identification of targets of the essential RNase
Y Mol Microbiol. 2011 Sep;81(6):1459-73. doi: 10.1111/j.1365-2958.2011.07777.x.
Epub 2011 Aug 4. PubMed PMID: 21815947.
Hirooka K, Kunikane S, Matsuoka H, Yoshida K, Kumamoto K, Tojo S, Fujita Y
Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH
operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in
response to flavonoids J Bacteriol. 2007 Jul;189(14):5170-82. Epub 2007 May 4.
PubMed PMID: 17483215; PubMed Central PMCID: PMC1951842.
Yoshida K, Ohki YH, Murata M, Kinehara M, Matsuoka H, Satomura T, Ohki R,
Kumano M, Yamane K, Fujita Y
Bacillus subtilis LmrA is a repressor of the lmrAB
and yxaGH operons: identification of its binding site and functional analysis of
lmrB and yxaGH J Bacteriol. 2004 Sep;186(17):5640-8. PubMed PMID: 15317768;
PubMed Central PMCID: PMC516806.
Kumano M, Fujita M, Nakamura K, Murata M, Ohki R, Yamane K
resistance mutations in two regions immediately downstream of the -10 region of
lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus
subtilis mutants Antimicrob Agents Chemother. 2003 Jan;47(1):432-5. PubMed PMID:
12499232; PubMed Central PMCID: PMC148993.