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Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

LmrA regulon

The LmrA regulon


  • Coordinates on the chromosome (coding sequence): 290,132 -> 290,698
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • TetR family
  • Paralogous protein(s)

  • QdoR
  • Kinetic information




    Effectors of protein activity

  • flavonoids such as quercetin serve as inducers, binding results in release from DNA PubMed
  • Structure



    Additional information

    Expression and Regulation


  • lmrA-lmrB PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • induced by flavonoids such as quercetin (LmrA)PubMed
  • Regulatory mechanism

  • LmrA: transcription repression PubMed
  • Additional information

  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed
  • Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Hirooka K

    Transcriptional response machineries of Bacillus subtilis conducive to plant growth promotion

    Biosci Biotechnol Biochem. 2014;78(9):1471-84. doi: 10.1080/09168451.2014.943689. PubMed PMID: 25209494.
    Cuthbertson L, Nodwell JR

    The TetR family of regulators

    Microbiol Mol Biol Rev. 2013 Sep;77(3):440-75. doi: 10.1128/MMBR.00018-13. Review. PubMed PMID: 24006471; PubMed Central PMCID: PMC3811609.

    Original publications

    Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J

    RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y

    Mol Microbiol. 2011 Sep;81(6):1459-73. doi: 10.1111/j.1365-2958.2011.07777.x. Epub 2011 Aug 4. PubMed PMID: 21815947.
    Hirooka K, Kunikane S, Matsuoka H, Yoshida K, Kumamoto K, Tojo S, Fujita Y

    Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids

    J Bacteriol. 2007 Jul;189(14):5170-82. Epub 2007 May 4. PubMed PMID: 17483215; PubMed Central PMCID: PMC1951842.
    Yoshida K, Ohki YH, Murata M, Kinehara M, Matsuoka H, Satomura T, Ohki R, Kumano M, Yamane K, Fujita Y

    Bacillus subtilis LmrA is a repressor of the lmrAB and yxaGH operons: identification of its binding site and functional analysis of lmrB and yxaGH

    J Bacteriol. 2004 Sep;186(17):5640-8. PubMed PMID: 15317768; PubMed Central PMCID: PMC516806.
    Kumano M, Fujita M, Nakamura K, Murata M, Ohki R, Yamane K

    Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants

    Antimicrob Agents Chemother. 2003 Jan;47(1):432-5. PubMed PMID: 12499232; PubMed Central PMCID: PMC148993.
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