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Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

The LutR regulon


  • Coordinates on the chromosome (coding sequence): 3,509,831 -> 3,510,490
  • The protein

    Catalyzed reaction/ biological activity

  • transcriptional repressor of the lutA-lutB-lutC operon PubMed
  • Protein family

  • GntR family of transcription factors
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • lactate acts as molecular inducer PubMed
  • Structure



    Additional information

    Expression and Regulation


    Sigma factor

  • SigA PubMed
  • Regulation

    Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-B607 (yvfI::erm), available at the NBRP B. subtilis, Japan
  • TEK1 lutR::Tn10::spc PubMed
  • Expression vector

  • pQE60-lutR (His-tag) PubMed
  • lacZ fusion

  • TEK7 lutR::lacZ::erm PubMed
  • GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein

  • Richard Losick, Harvard Univ., Cambridge, USA homepage
  • Ayten Katatas, Istanbul Technical University, Istanbul, Turkey x
  • References

    Chiu KC, Lin CJ, Shaw GC

    Transcriptional regulation of the l-lactate permease gene lutP by the LutR repressor of Bacillus subtilis RO-NN-1

    Microbiology. 2014 Oct;160(Pt 10):2178-89. doi: 10.1099/mic.0.079806-0. Epub 2014 Jul 16. PubMed PMID: 25031425.
    Irigül-Sönmez Ö, Köroğlu TE, Öztürk B, Kovács ÁT, Kuipers OP, Yazgan-Karataş A

    In Bacillus subtilis LutR is part of the global complex regulatory network governing the adaptation to the transition from exponential growth to stationary phase

    Microbiology. 2014 Feb;160(Pt 2):243-60. doi: 10.1099/mic.0.064675-0. Epub 2013 Nov 6. PubMed PMID: 24196425.
    Chai Y, Kolter R, Losick R

    A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation

    J Bacteriol. 2009 Apr;191(8):2423-30. doi: 10.1128/JB.01464-08. Epub 2009 Feb 6. PubMed PMID: 19201793; PubMed Central PMCID: PMC2668416.
    Köroğlu TE, Kurt-Gür G, Unlü EC, Yazgan-Karataş A

    The novel gene yvfI in Bacillus subtilis is essential for bacilysin biosynthesis

    Antonie Van Leeuwenhoek. 2008 Oct;94(3):471-9. doi: 10.1007/s10482-008-9265-8. Epub 2008 Jul 6. PubMed PMID: 18604637.
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