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Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, ManR regulon

The ManR regulon


  • Coordinates on the chromosome (coding sequence): 1,270,631 -> 1,272,577
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information



  • phosphorylation by ManP inactivates ManR (in the absence of mannose), phosphorylation by HPr stimluates ManR PubMed
  • Cofactors

    Effectors of protein activity




  • ManP-ManR PubMed
  • HPr-ManR PubMed
  • Additional information

    Expression and Regulation


  • manR PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • induced by mannose (ManR) PubMed
  • repressed by glucose (CcpA, ManR) PubMed
  • Regulatory mechanism

  • ManR: transcription activation in the presence of mannose and absence of glucose PubMed
  • CcpA: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-A269 (yjdC::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Wenzel M, Altenbuchner J

    The Bacillus subtilis mannose regulator, ManR, a DNA-binding protein regulated by HPr and its cognate PTS transporter ManP

    Mol Microbiol. 2013 May;88(3):562-76. doi: 10.1111/mmi.12209. Epub 2013 Apr 1. PubMed PMID: 23551403.
    Marciniak BC, Pabijaniak M, de Jong A, Dűhring R, Seidel G, Hillen W, Kuipers OP

    High- and low-affinity cre boxes for CcpA binding in Bacillus subtilis revealed by genome-wide analysis

    BMC Genomics. 2012 Aug 17;13:401. doi: 10.1186/1471-2164-13-401. PubMed PMID: 22900538; PubMed Central PMCID: PMC3463425.
    Sun T, Altenbuchner J

    Characterization of a mannose utilization system in Bacillus subtilis

    J Bacteriol. 2010 Apr;192(8):2128-39. doi: 10.1128/JB.01673-09. Epub 2010 Feb 5. PubMed PMID: 20139185; PubMed Central PMCID: PMC2849456.
    Reizer J, Bachem S, Reizer A, Arnaud M, Saier MH Jr, Stülke J

    Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis

    Microbiology. 1999 Dec;145 ( Pt 12):3419-29. PubMed PMID: 10627040.
    Stülke J, Arnaud M, Rapoport G, Martin-Verstraete I

    PRD--a protein domain involved in PTS-dependent induction and carbon catabolite repression of catabolic operons in bacteria

    Mol Microbiol. 1998 Jun;28(5):865-74. Review. PubMed PMID: 9663674.
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