SubtiBank SubtiBank
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Categories containing this gene/protein


transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons


Mta regulon

The Mta regulon


Gene


  • Coordinates on the chromosome (coding sequence): 3,764,133 -> 3,764,906
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

  • MerR family
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

  • 1JBG (N-terminal domain), 1R8D (complex of N-terminal domain with DNA)
  • Localization

  • cytoplasm (according to Swiss-Prot)
  • Interactions

    Additional information

    Expression and Regulation


    Operon

  • mta PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • positive autoregulation PubMed
  • Regulatory mechanism

  • Mta: transcription activation PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-A197 (ywnD::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


  • Mohamed Marahiel, Marburg University, Germany homepage
  • Richard Brennan, Houston, Texas, USA Homepage
  • References


    Miethke M, Schmidt S, Marahiel MA

    The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis

    J Bacteriol. 2008 Aug;190(15):5143-52. doi: 10.1128/JB.00464-08. PubMed PMID: 18502870; PubMed Central PMCID: PMC2493272.
    Newberry KJ, Brennan RG

    The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus

    J Biol Chem. 2004 May 7;279(19):20356-62. PubMed PMID: 14985361.
    Godsey MH, Baranova NN, Neyfakh AA, Brennan RG

    Crystal structure of MtaN, a global multidrug transporter gene activator

    J Biol Chem. 2001 Dec 14;276(50):47178-84. PubMed PMID: 11581256.
    Godsey MH, Baranova NN, Neyfakh AA, Brennan RG

    Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis

    Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1456-8. PubMed PMID: 11053850.
    Baranova NN, Danchin A, Neyfakh AA

    Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters

    Mol Microbiol. 1999 Mar;31(5):1549-59. PubMed PMID: 10200972.
    Presecan E, Moszer I, Boursier L, Cruz Ramos HC, de la Fuente V, Hullo MF, Lelong C, Schleich S, Sekowska A, Song BH, Villani G, Kunst F, Danchin A, Glaser P

    The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees)

    Microbiology. 1997 Oct;143 ( Pt 10):3313-28. PubMed PMID: 9353933.
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