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Categories containing this gene/protein

biosynthesis of cofactors, transcription factors and their control

This gene is a member of the following regulons

NadR regulon

The NadR regulon


  • Coordinates on the chromosome (coding sequence): 2,850,716 -> 2,851,258
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information




    Effectors of protein activity




    Additional information

    Expression and Regulation


  • nifS-nadR PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism

  • NadR: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-A824 (yrxA::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein

  • Alessandra Albertini, University of Pavia, Italy homepage
  • References

    Rodionov DA, Li X, Rodionova IA, Yang C, Sorci L, Dervyn E, Martynowski D, Zhang H, Gelfand MS, Osterman AL

    Transcriptional regulation of NAD metabolism in bacteria: genomic reconstruction of NiaR (YrxA) regulon

    Nucleic Acids Res. 2008 Apr;36(6):2032-46. doi: 10.1093/nar/gkn046. Epub 2008 Feb 14. PubMed PMID: 18276644; PubMed Central PMCID: PMC2330245.
    Rossolillo P, Marinoni I, Galli E, Colosimo A, Albertini AM

    YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis

    J Bacteriol. 2005 Oct;187(20):7155-60. PubMed PMID: 16199587; PubMed Central PMCID: PMC1251630.
    Sun D, Setlow P

    Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis

    J Bacteriol. 1993 Mar;175(5):1423-32. PubMed PMID: 8444804; PubMed Central PMCID: PMC193229.
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