natK

natK
168

two-component sensor kinase, regulation of the [gene|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936|natA]-[gene|A8ADA02BBB549866DE330040CF6D06ECC3B00099|natB] operon

locus
BSU_02730
Molecular weight
34.92 kDa
pI
8.05
Protein length
Gene length
function
regulation of the [gene|B019FD0CB6F76C03DA5E76ABD1B324BA5E1A6936|natA]-[gene|A8ADA02BBB549866DE330040CF6D06ECC3B00099|natB] operon
product
two-component sensor kinase
essential
no
synonyms
natK, yccG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3290 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
294,615  295,571
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The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of [protein|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR] in response to sodium availability
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
three transmembrane segments
[wiki|Histidine kinase domain] (aa 132-318) (according to UniProt)
Structure
[AF|P70954]
Modification
autophosphorylation on a His residue
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR]-[gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]
description
[pubmed|22383849]
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[gene|D3F6337B94A633730E514B05CA852BE9AA3741B3|natR]→[gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]

2024-03-19 17:55:40

Jstuelk

58

6033418d44d4ee934be10c40c9057897d0b92659

ACC0CCF7E3D9FD26556A01A19C0236CC1543064C

Biological materials
Mutant
MGNA-C042 (yccG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2040 NBRP B. subtilis, Japan]
BKE02730 ([gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02730 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AAGGGTAATCACGTACTAAA,  downstream forward: _UP4_TAAAAAAACCTTGAAAAGCC
BKK02730 ([gene|A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5|natK]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02730 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AAGGGTAATCACGTACTAAA,  downstream forward: _UP4_TAAAAAAACCTTGAAAAGCC
References
10094672,17322186

A4644CB18F7D0DF3E7E50ABB0C0F224D5744A1A5

Page visits: 3969

Time of last update: 2024-03-28 13:48:15

Author of last update: Melvin.boenninger