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Categories containing this gene/protein

metal ion homeostasis (K, Na, Ca, Mg), transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

The NatR regulon


  • Coordinates on the chromosome (coding sequence): 295,584 -> 296,285
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • OmpR family of two-component response regulators
  • Paralogous protein(s)

    Kinetic information



  • phosphorylated by NatK on an Asp residue
  • Cofactors

    Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity
  • Structure


  • cytoplasm (according to Swiss-Prot)
  • Interactions

  • NatK-NatR
  • Additional information

    Expression and Regulation


  • natR (according to DBTBS)
  • Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-C043 (yccH::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Ogura M, Tsukahara K, Hayashi K, Tanaka T

    The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion

    Microbiology. 2007 Mar;153(Pt 3):667-75. PubMed PMID: 17322186.
    Fabret C, Feher VA, Hoch JA

    Two-component signal transduction in Bacillus subtilis: how one organism sees its world

    J Bacteriol. 1999 Apr;181(7):1975-83. Review. PubMed PMID: 10094672; PubMed Central PMCID: PMC93607.
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