SubtiBank SubtiBank
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Categories containing this gene/protein


miscellaneous metabolic pathways, transcription factors and their control, biosynthesis of antibacterial compounds

This gene is a member of the following regulons


AbrB regulon

The NtdR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 1,129,715 -> 1,130,704
  • The protein


    Catalyzed reaction/ biological activity

  • transcription activation of the ntdA-ntdB-ntdC-glcP operon PubMed
  • Protein family

  • LacI family
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

    Localization

    Interactions

    Additional information

    Expression and Regulation


    Operon

  • ntdR PubMed
  • Sigma factor

    Regulation

    Regulatory mechanism

  • AbrB: transcription repression PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-A726 (yhjM::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Reviews

    Inaoka T(1), Ochi K.

    Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis.

    Biosci Biotechnol Biochem. 2011;75(4):618-23. Epub 2011 Apr 22.

    Original publications

    Chumsakul O, Takahashi H, Oshima T, Hishimoto T, Kanaya S, Ogasawara N, Ishikawa S

    Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation

    Nucleic Acids Res. 2011 Jan;39(2):414-28. doi: 10.1093/nar/gkq780. PubMed PMID: 20817675; PubMed Central PMCID: PMC3025583.
    Inaoka T, Ochi K

    Glucose uptake pathway-specific regulation of synthesis of neotrehalosadiamine, a novel autoinducer produced in Bacillus subtilis

    J Bacteriol. 2007 Jan;189(1):65-75. PubMed PMID: 17056753; PubMed Central PMCID: PMC1797211.
    Inaoka T, Takahashi K, Yada H, Yoshida M, Ochi K

    RNA polymerase mutation activates the production of a dormant antibiotic 3,3'-neotrehalosadiamine via an autoinduction mechanism in Bacillus subtilis

    J Biol Chem. 2004 Jan 30;279(5):3885-92. PubMed PMID: 14612444.
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