padR

padR
168

repressor of [gene|1E0BA378F14ADF03D613DA3BF3241C1ADE75075E|yveF]-[gene|1F56C126099E1D5241069E06477F277C12B20C58|yveG]-[gene|ECA64CB1E4BF8B6B0854B1B63C9E85A519059C6C|padC], induction occurs by binding of phenolic acids,stress response

locus
BSU_08340
Molecular weight
21.08 kDa
pI
7.23
Protein length
Gene length
function
regulation of the phenolic acid stress response
product
transcriptional repressor
essential
no
synonyms
padR, yfiO

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1695 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
909,198  909,746
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The protein
[wiki|Domains]
N-terminal winged helix-turn-helix (wHTH) domain (NTD) [pubmed|29136175]
C-terminal homodimerization domain (CTD) [pubmed|29136175]
Structure
[PDB|5X12] (PadR) [pubmed|29136175]
[PDB|5X11] (complex with dsDNA) [pubmed|29136175]
[PDB|5X13] (complex with p-coumaric acid) [pubmed|29136175]
[AF|P94443]
Effectors of protein activity
phenolic acid acts as molecular inducer and releases PadR from the'' [gene|1E0BA378F14ADF03D613DA3BF3241C1ADE75075E|yveF]-[gene|1F56C126099E1D5241069E06477F277C12B20C58|yveG]-[gene|ECA64CB1E4BF8B6B0854B1B63C9E85A519059C6C|padC]'' promoter [Pubmed|18326577]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|A7824EACE0C109C676A374FD21F59D671B703305|padR]
description
[pubmed|22383849]
regulation
weak constitutive expression
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[gene|A7824EACE0C109C676A374FD21F59D671B703305|padR]

2024-02-18 22:46:19

Jstuelk

49

5d0559d60fba2f89412a8b7d75307782208f5b11

B7BA9D129F16D518E718EE0AC9DFABDC30B07977

Biological materials
Mutant
MGNA-C303 (yfiO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2301 NBRP B. subtilis, Japan]
BKE08340 ([gene|A7824EACE0C109C676A374FD21F59D671B703305|padR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08340 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCTATCCTCCGTGTCTG,  downstream forward: _UP4_TAACCGCAGTTCAGGCTGCA
BKK08340 ([gene|A7824EACE0C109C676A374FD21F59D671B703305|padR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08340 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGCTATCCTCCGTGTCTG,  downstream forward: _UP4_TAACCGCAGTTCAGGCTGCA
References
18326577,21685295,29136175,32828288

A7824EACE0C109C676A374FD21F59D671B703305

Page visits: 3747

Time of last update: 2024-03-28 21:50:11

Author of last update: Jstuelk