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International Conference on Bacilli and Gram-positive bacteria

June 11 - 15, 2017, Berlin, Germany

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Categories containing this gene/protein

transcription factors and their control, resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

This gene is a member of the following regulons

The PadR regulon


  • Coordinates on the chromosome (coding sequence): 909,198 -> 909,746
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • phenolic acid acts as molecular inducer and releases PadR from the yveF-yveG-padC promoter PubMed
  • Structure


  • cytoplasm (according to Swiss-Prot)
  • Interactions

    Additional information

    Expression and Regulation


  • padR (according to DBTBS)
  • Sigma factor


  • weak constitutive expression
  • Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-C303 (yfiO::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Nguyen TK, Tran NP, Cavin JF

    Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168

    J Bacteriol. 2011 Aug;193(16):4180-91. doi: 10.1128/JB.00385-11. Epub 2011 Jun 17. PubMed PMID: 21685295; PubMed Central PMCID: PMC3147689.
    Tran NP, Gury J, Dartois V, Nguyen TK, Seraut H, Barthelmebs L, Gervais P, Cavin JF

    Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis

    J Bacteriol. 2008 May;190(9):3213-24. doi: 10.1128/JB.01936-07. Epub 2008 Mar 7. PubMed PMID: 18326577; PubMed Central PMCID: PMC2347383.
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