SubtiBank SubtiBank
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Categories containing this gene/protein


ABC transporters, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons


PsdR regulon

Gene


  • Coordinates on the chromosome (coding sequence): 3,565,496 -> 3,566,275
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

  • 1L2T (MJ0796 from Methanocaldococcus jannaschii , 44% identity) PubMed
  • Localization

  • membrane associated (via PsdB) PubMed
  • Interactions

  • PsdA-PsdB PubMed
  • Additional information

    Expression and Regulation


    Operon

  • psdA-psdB PubMed
  • psdR-psdS-psdA-psdB PubMed
  • Sigma factor

  • psdA: SigA PubMed
  • psdR: SigA PubMed
  • Regulation

  • psdA: induced by nisin, gallidermin (PsdR) PubMed
  • strongly induced in the stationary phase due to the internal production of toxic peptides (SdpC, SkfA) (PsdR) PubMed
  • strong induction by SkfA, weaker induction by SdpC PubMed
  • Regulatory mechanism

  • PsdR: transcription activation PubMed
  • Additional information

    Biological materials


    Mutant

  • MGNA-B635 (yvcR::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Fang C, Nagy-Staroń A, Grafe M, Heermann R, Jung K, Gebhard S, Mascher T

    Insulation and wiring specificity of BceR-like response regulators and their target promoters in Bacillus subtilis

    Mol Microbiol. 2017 Apr;104(1):16-31. doi: 10.1111/mmi.13597. Epub 2017 Jan 27. PubMed PMID: 27997719.
    Höfler C, Heckmann J, Fritsch A, Popp P, Gebhard S, Fritz G, Mascher T

    Cannibalism stress response in Bacillus subtilis

    Microbiology. 2016 Jan;162(1):164-76. doi: 10.1099/mic.0.000176. Epub 2015 Sep 11. PubMed PMID: 26364265.
    Coumes-Florens S, Brochier-Armanet C, Guiseppi A, Denizot F, Foglino M

    A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system

    PLoS One. 2011 Jan 19;6(1):e15951. doi: 10.1371/journal.pone.0015951. PubMed PMID: 21283517; PubMed Central PMCID: PMC3023708.
    Rietkötter E, Hoyer D, Mascher T

    Bacitracin sensing in Bacillus subtilis

    Mol Microbiol. 2008 May;68(3):768-85. doi: 10.1111/j.1365-2958.2008.06194.x. PubMed PMID: 18394148.
    Smith PC, Karpowich N, Millen L, Moody JE, Rosen J, Thomas PJ, Hunt JF

    ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

    Mol Cell. 2002 Jul;10(1):139-49. PubMed PMID: 12150914; PubMed Central PMCID: PMC3516284.
    Quentin Y, Fichant G, Denizot F

    Inventory, assembly and analysis of Bacillus subtilis ABC transport systems

    J Mol Biol. 1999 Apr 2;287(3):467-84. PubMed PMID: 10092453.
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