SubtiBank SubtiBank

Description: two-component response regulator (OmpR family), induction of psdA-psdB in response to lipid II-binding lantibiotics (nisin and gallidermin) and internal antimicrobial peptides (SdpC, SkfA)

Name: psdR
Locus: BSU34720BsubCyc
pI: 4.0
MW: 27.0 kDa
Protein length: 237 aaBLASTSequence
Gene length: 711 bpBLASTSequenceSequence + Flanks
Function: resistance against toxic peptides
Product: two-component response regulator (OmpR family)
Essential: no
E.C. number:
Synonyms: yvcP
Databases: SubtiListKEGGUniProtExpression data browser

Categories containing this gene/protein


transcription factors and their control, resistance against toxins/ antibiotics, phosphoproteins

This gene is a member of the following regulons


The PsdR regulon


Gene


  • Coordinates on the chromosome (coding sequence): 3,567,422 -> 3,568,135
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

  • OmpR family of two-component response regulators
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

  • phosphorylated by PsdS on an Asp residue
  • Cofactors

    Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity
  • Structure

    Localization

  • cytoplasm (according to Swiss-Prot)
  • Interactions

  • PsdR-PsdS
  • Additional information

    Expression and Regulation


    Operon

  • psdR-psdS-psdA-psdB PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

    Regulatory mechanism

    Additional information

    Biological materials


    Mutant

  • MGNA-B637 (yvcP::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Fang C, Nagy-Staroń A, Grafe M, Heermann R, Jung K, Gebhard S, Mascher T

    Insulation and wiring specificity of BceR-like response regulators and their target promoters in Bacillus subtilis

    Mol Microbiol. 2017 Apr;104(1):16-31. doi: 10.1111/mmi.13597. Epub 2017 Jan 27. PubMed PMID: 27997719.
    Zhang S, Li X, Wang X, Li Z, He J

    The two-component signal transduction system YvcPQ regulates the bacterial resistance to bacitracin in Bacillus thuringiensis

    Arch Microbiol. 2016 Oct;198(8):773-84. doi: 10.1007/s00203-016-1239-z. Epub 2016 May 17. PubMed PMID: 27188294.
    Höfler C, Heckmann J, Fritsch A, Popp P, Gebhard S, Fritz G, Mascher T

    Cannibalism stress response in Bacillus subtilis

    Microbiology. 2016 Jan;162(1):164-76. doi: 10.1099/mic.0.000176. Epub 2015 Sep 11. PubMed PMID: 26364265.
    Leyn SA, Kazanov MD, Sernova NV, Ermakova EO, Novichkov PS, Rodionov DA

    Genomic reconstruction of the transcriptional regulatory network in Bacillus subtilis

    J Bacteriol. 2013 Jun;195(11):2463-73. doi: 10.1128/JB.00140-13. Epub 2013 Mar 15. PubMed PMID: 23504016; PubMed Central PMCID: PMC3676070.
    Coumes-Florens S, Brochier-Armanet C, Guiseppi A, Denizot F, Foglino M

    A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system

    PLoS One. 2011 Jan 19;6(1):e15951. doi: 10.1371/journal.pone.0015951. PubMed PMID: 21283517; PubMed Central PMCID: PMC3023708.
    Staroń A, Finkeisen DE, Mascher T

    Peptide antibiotic sensing and detoxification modules of Bacillus subtilis

    Antimicrob Agents Chemother. 2011 Feb;55(2):515-25. doi: 10.1128/AAC.00352-10. Epub 2010 Nov 15. PubMed PMID: 21078927; PubMed Central PMCID: PMC3028804.
    Rietkötter E, Hoyer D, Mascher T

    Bacitracin sensing in Bacillus subtilis

    Mol Microbiol. 2008 May;68(3):768-85. doi: 10.1111/j.1365-2958.2008.06194.x. PubMed PMID: 18394148.
    Mascher T, Margulis NG, Wang T, Ye RW, Helmann JD

    Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon

    Mol Microbiol. 2003 Dec;50(5):1591-604. PubMed PMID: 14651641.
    Fabret C, Feher VA, Hoch JA

    Two-component signal transduction in Bacillus subtilis: how one organism sees its world

    J Bacteriol. 1999 Apr;181(7):1975-83. Review. PubMed PMID: 10094672; PubMed Central PMCID: PMC93607.
    No login