rapC
168
response regulator aspartate phosphatase, controls [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] activity
locus
BSU_03770
Molecular weight
45.47 kDa
pI
5.02
function
control of [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] activity
product
response regulator aspartate phosphatase
essential
no
synonyms
rapC, yclL
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
428,831 429,979
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The protein
Catalyzed reaction/ biological activity
control of [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] activity [Pubmed|12950917]
Protein family
[wiki|RAP family] (according to UniProt)
[wiki|Domains]
five [wiki|TPR repeat|tetratricopeptide repeats] (according to UniProt)
Structure
[PDB|4I9E] ([protein|1F860F4E66A3D503D5A97F17D4AB0504BEFE7F9D|rapF], 57% identity) [pubmed|23526880]
[AF|P94415]
Effectors of protein activity
binding of [protein|C0B7845F55A16300EB37F026C817AEC4F3BA3B6F|phrC] to [protein|242632B27E0E3AB15777E9FBA3FC746D00CE97F9|rapC] prevents it from binding [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA] [Pubmed|12950917]
Expression and Regulation
Operons
genes
[gene|242632B27E0E3AB15777E9FBA3FC746D00CE97F9|rapC]-[gene|C0B7845F55A16300EB37F026C817AEC4F3BA3B6F|phrC]
description
[Pubmed|10464187]
regulation
expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|10464187], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
[protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]) [Pubmed|16091051], in [regulon|protein:7832489F11F606BCF637EC23BAAB41AD10237EBB|comA regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, [Pubmed|12850135], in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|10464187], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|10464187], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
Biological materials
Mutant
MGNA-C065 (rapC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2063 NBRP B. subtilis, Japan]
BKE03770 ([gene|242632B27E0E3AB15777E9FBA3FC746D00CE97F9|rapC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE03770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCCTTCACCCTCTCCCA, downstream forward: _UP4_CAAATACAAAGGAGTGAAGG
BKK03770 ([gene|242632B27E0E3AB15777E9FBA3FC746D00CE97F9|rapC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK03770 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCCTTCACCCTCTCCCA, downstream forward: _UP4_CAAATACAAAGGAGTGAAGG
References
Reviews
Original Publications
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Time of last update: 2024-04-15 22:40:17
Author of last update: Jstuelk