SubtiBank SubtiBank

Categories containing this gene/protein


respiration, essential genes, membrane proteins

This gene is a member of the following regulons


CcpA regulon, PhoP regulon, ResD regulon

Gene


  • Coordinates on the chromosome (coding sequence): 2,419,179 -> 2,420,807
  • Phenotypes of a mutant

  • essential PubMed
  • The protein


    Catalyzed reaction/ biological activity

  • haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane PubMed
  • Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

    Localization

  • cell membrane ResB-ResC PubMed
  • Interactions

  • ResB-ResC PubMed
  • Additional information

    Expression and Regulation


    Operon

    Sigma factor

  • SigA PubMed
  • Regulation

  • expressed under anaerobic conditions (ResD) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed
  • repressed by glucose (CcpA) PubMed
  • Regulatory mechanism

  • ResD: transcription activation PubMed
  • PhoP: transcription activation PubMed
  • CcpA: transcription repression PubMed
  • Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Ahuja U, Kjelgaard P, Schulz BL, Thöny-Meyer L, Hederstedt L

    Haem-delivery proteins in cytochrome c maturation System II

    Mol Microbiol. 2009 Sep;73(6):1058-71. doi: 10.1111/j.1365-2958.2009.06833.x. Epub 2009 Aug 11. PubMed PMID: 19682263.
    Choi SK, Saier MH Jr

    Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis

    J Mol Microbiol Biotechnol. 2006;11(1-2):104-10. PubMed PMID: 16825793.
    Nakano MM, Zhu Y

    Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth

    J Bacteriol. 2001 Mar;183(6):1938-44. PubMed PMID: 11222591; PubMed Central PMCID: PMC95088.
    Le Brun NE, Bengtsson J, Hederstedt L

    Genes required for cytochrome c synthesis in Bacillus subtilis

    Mol Microbiol. 2000 May;36(3):638-50. PubMed PMID: 10844653.
    Birkey SM, Liu W, Zhang X, Duggan MF, Hulett FM

    Pho signal transduction network reveals direct transcriptional regulation of one two-component system by another two-component regulator: Bacillus subtilis PhoP directly regulates production of ResD

    Mol Microbiol. 1998 Dec;30(5):943-53. PubMed PMID: 9988472.
    Sun G, Sharkova E, Chesnut R, Birkey S, Duggan MF, Sorokin A, Pujic P, Ehrlich SD, Hulett FM

    Regulators of aerobic and anaerobic respiration in Bacillus subtilis

    J Bacteriol. 1996 Mar;178(5):1374-85. PubMed PMID: 8631715; PubMed Central PMCID: PMC177812.
    Sun G, Sharkova E, Chesnut R, Birkey S, Duggan MF, Sorokin A, Pujic P, Ehrlich SD, Hulett FM

    Regulators of aerobic and anaerobic respiration in Bacillus subtilis

    J Bacteriol. 1996 Mar;178(5):1374-85. PubMed PMID: 8631715; PubMed Central PMCID: PMC177812.
    No login