SubtiBank SubtiBank

Categories containing this gene/protein


respiration, membrane proteins

This gene is a member of the following regulons


CcpA regulon, PhoP regulon, ResD regulon

Gene


  • Coordinates on the chromosome (coding sequence): 2,419,179 -> 2,420,807
  • Phenotypes of a mutant

  • essential PubMed, non-essential according to PubMed
  • The protein


    Catalyzed reaction/ biological activity

  • haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane PubMed
  • Protein family

    Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

    Localization

  • cell membrane ResB-ResC PubMed
  • Interactions

  • ResB-ResC PubMed
  • Additional information

    Expression and Regulation


    Operon

    Sigma factor

  • SigA PubMed
  • Regulation

  • expressed under anaerobic conditions (ResD) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed
  • repressed by glucose (CcpA) PubMed
  • Regulatory mechanism

  • ResD: transcription activation PubMed
  • PhoP: transcription activation PubMed
  • CcpA: transcription repression PubMed
  • Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Koo BM, Kritikos G, Farelli JD, Todor H, Tong K, Kimsey H, Wapinski I, Galardini M, Cabal A, Peters JM, Hachmann AB, Rudner DZ, Allen KN, Typas A, Gross CA

    Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis

    Cell Syst. 2017 Mar 22;4(3):291-305.e7. doi: 10.1016/j.cels.2016.12.013. Epub 2017 Feb 8. PubMed PMID: 28189581; PubMed Central PMCID: PMC5400513.
    Ahuja U, Kjelgaard P, Schulz BL, Thöny-Meyer L, Hederstedt L

    Haem-delivery proteins in cytochrome c maturation System II

    Mol Microbiol. 2009 Sep;73(6):1058-71. doi: 10.1111/j.1365-2958.2009.06833.x. Epub 2009 Aug 11. PubMed PMID: 19682263.
    Choi SK, Saier MH Jr

    Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis

    J Mol Microbiol Biotechnol. 2006;11(1-2):104-10. PubMed PMID: 16825793.
    Nakano MM, Zhu Y

    Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth

    J Bacteriol. 2001 Mar;183(6):1938-44. PubMed PMID: 11222591; PubMed Central PMCID: PMC95088.
    Le Brun NE, Bengtsson J, Hederstedt L

    Genes required for cytochrome c synthesis in Bacillus subtilis

    Mol Microbiol. 2000 May;36(3):638-50. PubMed PMID: 10844653.
    Birkey SM, Liu W, Zhang X, Duggan MF, Hulett FM

    Pho signal transduction network reveals direct transcriptional regulation of one two-component system by another two-component regulator: Bacillus subtilis PhoP directly regulates production of ResD

    Mol Microbiol. 1998 Dec;30(5):943-53. PubMed PMID: 9988472.
    Sun G, Sharkova E, Chesnut R, Birkey S, Duggan MF, Sorokin A, Pujic P, Ehrlich SD, Hulett FM

    Regulators of aerobic and anaerobic respiration in Bacillus subtilis

    J Bacteriol. 1996 Mar;178(5):1374-85. PubMed PMID: 8631715; PubMed Central PMCID: PMC177812.
    Sun G, Sharkova E, Chesnut R, Birkey S, Duggan MF, Sorokin A, Pujic P, Ehrlich SD, Hulett FM

    Regulators of aerobic and anaerobic respiration in Bacillus subtilis

    J Bacteriol. 1996 Mar;178(5):1374-85. PubMed PMID: 8631715; PubMed Central PMCID: PMC177812.
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