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Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon, RhaR regulon

The RhaR regulon


  • Coordinates on the chromosome (coding sequence): 3,201,027 -> 3,201,803
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • molecular inducer: rhamnulose-1-phosphate PubMed
  • Structure



    Additional information

    Expression and Regulation


  • rhaEW-rhaR-rhaB-rhaM-rhaA PubMed
  • rhaR-rhaB-rhaM-rhaA PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • induced by rhamnose (molecular inducer: rhamnulose-1-phosphate) (RhaR) PubMed
  • repressed in the presence of glucose and other preferred carbon sources (CcpA) PubMed
  • Regulatory mechanism

  • RhaR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-B546 (yulB::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Hirooka K, Kodoi Y, Satomura T, Fujita Y

    Regulation of the rhaEWRBMA Operon Involved in l-Rhamnose Catabolism through Two Transcriptional Factors, RhaR and CcpA, in Bacillus subtilis

    J Bacteriol. 2015 Dec 28;198(5):830-45. doi: 10.1128/JB.00856-15. PubMed PMID: 26712933; PubMed Central PMCID: PMC4810612.
    Rodionova IA, Li X, Thiel V, Stolyar S, Stanton K, Fredrickson JK, Bryant DA, Osterman AL, Best AA, Rodionov DA

    Comparative genomics and functional analysis of rhamnose catabolic pathways and regulons in bacteria

    Front Microbiol. 2013 Dec 23;4:407. doi: 10.3389/fmicb.2013.00407. eCollection 2013. PubMed PMID: 24391637; PubMed Central PMCID: PMC3870299.
    Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P

    Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis

    Science. 2012 Mar 2;335(6072):1103-6. doi: 10.1126/science.1206848. PubMed PMID: 22383849.
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