rnpB

rnpB
168

RNA component of RNase P

locus
BSU_misc_RNA_35
Gene length
function
cleavage of precursor sequences from the 5 ends of pre-tRNAs
product
RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)
essential
yes
synonyms
rnpB, rnaP

Genomic Context

Categories containing this gene/protein

This gene is a member of the following regulons

Gene
Phenotypes of a mutant
essential [Pubmed|23109554]
RNA
Catalyzed reaction/ biological activity
processing of tRNAs
Effectors of RNA activity
[protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM] [pubmed|38050972]
additional information
KD ([protein|594F2D36BE71A45303A33AA2A2931F56F0A969ED|rnpA]-[protein|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] interaction): 40 nM [pubmed|15337847]
KD ([protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM]-[protein|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] interaction): 460 pM [pubmed|38050972]
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The protein
Structure
[PDB|3DHS] catalytic domain of Geobacillus stearothermophilus RNase P RNA [pubmed|19095619]
[PDB|3Q1R] (complex of [protein|594F2D36BE71A45303A33AA2A2931F56F0A969ED|rnpA] with [protein|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB] and [gene|3B6620F44EC08BA9B02FE9359A5F74C6CAE6D4FB|trnA-Ile], from ''Thermotoga maritima'') [Pubmed|21076397]
Expression and Regulation
Operons
genes
[gene|C22F7704DC9D36D96FE089ADCEA546D7A3FB3739|gpsB]-[gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB]-[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]
description
[Pubmed|22383849]
Open in new tab

[gene|C22F7704DC9D36D96FE089ADCEA546D7A3FB3739|gpsB]→[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]

2024-03-11 09:52:45

Jstuelk

76

8fcfca7cc774f7208694093f3eb33cc2d7e072e9

2C2BA652C53582B304B290D6B627337B746C0EDC

genes
[gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB]-[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]
description
[Pubmed|22383849]
Open in new tab

[gene|57A79AAF00243B5E058FA901D43AA7B55CA33F63|rnpB]→[gene|0DF27BEAF763545258CE7DD56F65CD5BF74DD887|ypsC]

2024-01-31 23:03:37

Jstuelk

63

c4e04800212f758ea89de5ad1ce201d4b4e5d157

9ACE8ABB3AE3C4F91EC780F28948BB245F110A31

labs
[wiki|Carol Fierke], University of Michigan, Ann Arbor, USA [https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=fierke homepage]
[wiki|Roland Hartmann], Marburg University, Germany [http://www.pharmazie.uni-marburg.de/pharmchem/akhartmann/ag_hartmann.htm homepage]
References
Reviews
19215776,17868095,14691942,16650980,16980936,16679018,14550630,31464530,35787606,38479802
Original Publications
16470227,17355991,11812129,10390342,11454206,19549719,11454206,19717440,20133747,19932118,20188108,20434461,17299131,14510496,25402410,12951523,12836338,11577704,20557101,25352137,23109554,21076397,21622899,29116782,21076397,31003868,31993626,31993626,32826323,34864869,19095619,36840557,12390025,11233980,38050972,15337847

57A79AAF00243B5E058FA901D43AA7B55CA33F63

Page visits: 4956

Time of last update: 2024-03-23 10:17:19

Author of last update: Jstuelk