SubtiBank SubtiBank

Categories containing this gene/protein


miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons


AbrB regulon, ResD regulon, Rok regulon

Gene


  • Coordinates on the chromosome (coding sequence): 3,836,058 -> 3,836,189
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

  • bacteriocin class V family (according to Swiss-Prot)
  • Paralogous protein(s)

    Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

  • 1PXQ
  • Localization

  • secreted (according to Swiss-Prot)
  • Interactions

    Additional information

    Expression and Regulation


    Operon

  • sboA-sboX-albA-albB-albC-albD-albE-albF-albG PubMed
  • Sigma factor

  • SigA PubMed PubMed
  • Regulation

  • repressed by Rok PubMed
  • expressed under anaerobic conditions (ResD) PubMed
  • repressed during logrithmic growth (AbrB) PubMed
  • Regulatory mechanism

  • Rok: transcription repression PubMed
  • ResD: transcription activation PubMed
  • AbrB: transcription repression PubMed
  • Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Strauch MA, Bobay BG, Cavanagh J, Yao F, Wilson A, Le Breton Y

    Abh and AbrB control of Bacillus subtilis antimicrobial gene expression

    J Bacteriol. 2007 Nov;189(21):7720-32. PubMed PMID: 17720793; PubMed Central PMCID: PMC2168746.
    Albano M, Smits WK, Ho LT, Kraigher B, Mandic-Mulec I, Kuipers OP, Dubnau D

    The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions

    J Bacteriol. 2005 Mar;187(6):2010-9. PubMed PMID: 15743949; PubMed Central PMCID: PMC1064057.
    Nakano MM, Zheng G, Zuber P

    Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of signal transduction under anaerobic conditions in Bacillus subtilis

    J Bacteriol. 2000 Jun;182(11):3274-7. PubMed PMID: 10809710; PubMed Central PMCID: PMC94517.
    Zheng G, Hehn R, Zuber P

    Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity

    J Bacteriol. 2000 Jun;182(11):3266-73. PubMed PMID: 10809709; PubMed Central PMCID: PMC94516.
    Zheng G, Yan LZ, Vederas JC, Zuber P

    Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin

    J Bacteriol. 1999 Dec;181(23):7346-55. PubMed PMID: 10572140; PubMed Central PMCID: PMC103699.
    Zheng G, Yan LZ, Vederas JC, Zuber P

    Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin

    J Bacteriol. 1999 Dec;181(23):7346-55. PubMed PMID: 10572140; PubMed Central PMCID: PMC103699.
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