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Categories containing this gene/protein

transcription factors and their control, transition state regulators, phosphoproteins

This gene is a member of the following regulons

AbrB regulon, CodY regulon, SalA regulon, SenS regulon

The ScoC regulon


  • Coordinates on the chromosome (coding sequence): 1,073,106 -> 1,073,717
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information



  • phosphorylated on Arg-3 PubMed
  • Cofactors

    Effectors of protein activity

  • activity is inhibited in an unknown way by PrkA (possibly phosphorylation) PubMed
  • Structure

  • 2FXA
  • Localization


  • SinR-ScoC
  • Additional information

    Expression and Regulation


  • scoC PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • expressed upon transition into the stationary phase (AbrB) PubMed
  • Regulatory mechanism

  • AbrB: transcription activation PubMed
  • SenS: positive regulation PubMed
  • SalA: negative regulation PubMed
  • CodY: negative regulation PubMed
  • Additional information

    Biological materials


  • 1A918 ( scoC::erm trpC2 leuC7), PubMed, available at the Bacillus Genetic Stock Center
  • BKE09990 ( scoC::erm trpC2) is available at the Bacillus Genetic Stock Center
  • Expression vector

  • for expression, purification in E. coli with N-terminal His-tag, pRSETA available in Gerth lab
  • lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Barbieri G, Albertini AM, Ferrari E, Sonenshein AL, Belitsky BR

    Interplay of CodY and ScoC in the Regulation of Major Extracellular Protease Genes of Bacillus subtilis

    J Bacteriol. 2016 Jan 4;198(6):907-20. doi: 10.1128/JB.00894-15. PubMed PMID: 26728191; PubMed Central PMCID: PMC4772597.
    Belitsky BR, Brinsmade SR, Sonenshein AL

    Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB

    PLoS Genet. 2015 Oct 16;11(10):e1005600. doi: 10.1371/journal.pgen.1005600. eCollection 2015 Oct. PubMed PMID: 26473603; PubMed Central PMCID: PMC4608796.
    Yan J, Zou W, Fang J, Huang X, Gao F, He Z, Zhang K, Zhao N

    Eukaryote-like Ser/Thr protein kinase PrkA modulates sporulation via regulating the transcriptional factor σ(K) in Bacillus subtilis

    Front Microbiol. 2015 Apr 30;6:382. doi: 10.3389/fmicb.2015.00382. eCollection 2015. PubMed PMID: 25983726; PubMed Central PMCID: PMC4415436.
    Belitsky BR, Barbieri G, Albertini AM, Ferrari E, Strauch MA, Sonenshein AL

    Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC

    Mol Microbiol. 2015 Aug;97(4):698-716. doi: 10.1111/mmi.13056. Epub 2015 Jun 6. PubMed PMID: 25966844; PubMed Central PMCID: PMC4550321.
    Gupta M, Dixit M, Rao KK

    Spo0A positively regulates epr expression by negating the repressive effect of co-repressors, SinR and ScoC, in Bacillus subtilis

    J Biosci. 2013 Jun;38(2):291-9. PubMed PMID: 23660663.
    Elsholz AK, Turgay K, Michalik S, Hessling B, Gronau K, Oertel D, Mäder U, Bernhardt J, Becher D, Hecker M, Gerth U

    Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis

    Proc Natl Acad Sci U S A. 2012 May 8;109(19):7451-6. doi: 10.1073/pnas.1117483109. Epub 2012 Apr 19. PubMed PMID: 22517742; PubMed Central PMCID: PMC3358850.
    Kaushal B, Paul S, Hulett FM

    Direct regulation of Bacillus subtilis phoPR transcription by transition state regulator ScoC

    J Bacteriol. 2010 Jun;192(12):3103-13. doi: 10.1128/JB.00089-10. Epub 2010 Apr 9. PubMed PMID: 20382764; PubMed Central PMCID: PMC2901694.
    Kodgire P, Rao KK

    A dual mode of regulation of flgM by ScoC in Bacillus subtilis

    Can J Microbiol. 2009 Aug;55(8):983-9. doi: 10.1139/w09-049. PubMed PMID: 19898538.
    Inaoka T, Wang G, Ochi K

    ScoC regulates bacilysin production at the transcription level in Bacillus subtilis

    J Bacteriol. 2009 Dec;191(23):7367-71. doi: 10.1128/JB.01081-09. Epub 2009 Oct 2. PubMed PMID: 19801406; PubMed Central PMCID: PMC2786573.
    Abe S, Yasumura A, Tanaka T

    Regulation of Bacillus subtilis aprE expression by glnA through inhibition of scoC and sigma(D)-dependent degR expression

    J Bacteriol. 2009 May;191(9):3050-8. doi: 10.1128/JB.00049-09. Epub 2009 Feb 27. PubMed PMID: 19251843; PubMed Central PMCID: PMC2681795.
    Kodgire P, Rao KK

    hag expression in Bacillus subtilis is both negatively and positively regulated by ScoC

    Microbiology. 2009 Jan;155(Pt 1):142-9. doi: 10.1099/mic.0.021899-0. PubMed PMID: 19118355.
    Kodgire P, Dixit M, Rao KK

    ScoC and SinR negatively regulate epr by corepression in Bacillus subtilis

    J Bacteriol. 2006 Sep;188(17):6425-8. PubMed PMID: 16923912; PubMed Central PMCID: PMC1595376.
    Kawachi E, Abe S, Tanaka T

    Inhibition of Bacillus subtilis scoC expression by multicopy senS

    J Bacteriol. 2005 Dec;187(24):8526-30. PubMed PMID: 16321961; PubMed Central PMCID: PMC1317019.
    Ogura M, Matsuzawa A, Yoshikawa H, Tanaka T

    Bacillus subtilis SalA (YbaL) negatively regulates expression of scoC, which encodes the repressor for the alkaline exoprotease gene, aprE

    J Bacteriol. 2004 May;186(10):3056-64. PubMed PMID: 15126467; PubMed Central PMCID: PMC400612.
    Sánchez A, Olmos J

    Bacillus subtilis transcriptional regulators interaction

    Biotechnol Lett. 2004 Mar;26(5):403-7. PubMed PMID: 15104138.
    Shafikhani SH, Núñez E, Leighton T

    ScoC mediates catabolite repression of sporulation in Bacillus subtilis

    Curr Microbiol. 2003 Oct;47(4):327-36. PubMed PMID: 14629015.
    Caldwell R, Sapolsky R, Weyler W, Maile RR, Causey SC, Ferrari E

    Correlation between Bacillus subtilis scoC phenotype and gene expression determined using microarrays for transcriptome analysis

    J Bacteriol. 2001 Dec;183(24):7329-40. PubMed PMID: 11717292; PubMed Central PMCID: PMC95582.
    Koide A, Perego M, Hoch JA

    ScoC regulates peptide transport and sporulation initiation in Bacillus subtilis

    J Bacteriol. 1999 Jul;181(13):4114-7. PubMed PMID: 10383984; PubMed Central PMCID: PMC93906.
    Perego M, Hoch JA

    Sequence analysis and regulation of the hpr locus, a regulatory gene for protease production and sporulation in Bacillus subtilis

    J Bacteriol. 1988 Jun;170(6):2560-7. PubMed PMID: 3131303; PubMed Central PMCID: PMC211172.
    Dowds BC, Hoch JA

    Regulation of the oxidative stress response by the hpr gene in Bacillus subtilis

    J Gen Microbiol. 1991 May;137(5):1121-5. PubMed PMID: 1907636.
    Kallio PT, Fagelson JE, Hoch JA, Strauch MA

    The transition state regulator Hpr of Bacillus subtilis is a DNA-binding protein

    J Biol Chem. 1991 Jul 15;266(20):13411-7. PubMed PMID: 1906467.
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