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Categories containing this gene/protein

transcription factors and their control, toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

AbrB regulon, SdpR regulon

The SdpR regulon


  • Coordinates on the chromosome (coding sequence): 3,467,054 -> 3,467,326
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • ArsR family
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • SdpI binds and sequesters SdpR if extracellular SdpC is present, this results in induction of the sdpR-sdpI operon PubMed
  • Structure


  • cytoplasm (according to Swiss-Prot)
  • Interactions

  • SdpI-SdpR PubMed
  • Additional information

    Expression and Regulation


  • sdpR-sdpI PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • repressed during logrithmic growth (AbrB) PubMed
  • induced by extracellular SdpC (SdpR) PubMed
  • Regulatory mechanism

  • AbrB: transcription repression PubMed
  • SdpR: transcription repression PubMed
  • Additional information

    Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    González-Pastor JE(1).

    Cannibalism: a social behavior in sporulating Bacillus subtilis.

    FEMS Microbiol Rev. 2011 May;35(3):415-24. doi: 10.1111/j.1574-6976.2010.00253.x. Epub 2010 Oct 19.DOI: 10.1111/j.1574-6976.2010.00253.x PMID: 20955377 [Indexed for MEDLINE]

    Original Publications

    Ellermeier CD, Hobbs EC, Gonzalez-Pastor JE, Losick R

    A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin

    Cell. 2006 Feb 10;124(3):549-59. PubMed PMID: 16469701.
    González-Pastor JE, Hobbs EC, Losick R

    Cannibalism by sporulating bacteria

    Science. 2003 Jul 25;301(5632):510-3. Epub 2003 Jun 19. PubMed PMID: 12817086.
    Turner MS, Helmann JD

    Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the sigma(X) and sigma(W) factors in Bacillus subtilis

    J Bacteriol. 2000 Sep;182(18):5202-10. PubMed PMID: 10960106; PubMed Central PMCID: PMC94670.
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