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Categories containing this gene/protein


transcription factors and their control, sporulation proteins

This gene is a member of the following regulons


SigF regulon, SigG regulon

The SpoVT regulon


Gene


  • Coordinates on the chromosome (coding sequence): 64,099 -> 64,635
  • The protein


    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

  • AbrB, Abh (only the N-terminal domains (aa 1 through 50) are conserved between SpoVT and the two paralogues)
  • Kinetic information

    Domains

    Modification

    Cofactors

    Effectors of protein activity

    Structure

  • 2W1R (full-length), 2W1T (C-terminal domain) 2RO5 (recognition domain)
  • Localization

  • Cytoplasm (Homogeneous) PubMed
  • Interactions

    Additional information

    Expression and Regulation


    Operon

  • spoVT PubMed
  • Sigma factor

  • SigF PubMed, SigG PubMed
  • Regulation

  • expressed in the forespore (SigG) PubMed
  • Regulatory mechanism

    Additional information

    Biological materials


    Mutant

    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct

    Antibody

    Labs working on this gene/protein


    References


    Eijlander RT, Holsappel S, de Jong A, Ghosh A, Christie G, Kuipers OP

    SpoVT: From Fine-Tuning Regulator in Bacillus subtilis to Essential Sporulation Protein in Bacillus cereus

    Front Microbiol. 2016 Oct 13;7:1607. eCollection 2016. PubMed PMID: 27790204; PubMed Central PMCID: PMC5061766.
    Ramirez-Peralta A, Stewart KA, Thomas SK, Setlow B, Chen Z, Li YQ, Setlow P

    Effects of the SpoVT regulatory protein on the germination and germination protein levels of spores of Bacillus subtilis

    J Bacteriol. 2012 Jul;194(13):3417-25. doi: 10.1128/JB.00504-12. Epub 2012 Apr 20. PubMed PMID: 22522895; PubMed Central PMCID: PMC3434735.
    Asen I, Djuranovic S, Lupas AN, Zeth K

    Crystal structure of SpoVT, the final modulator of gene expression during spore development in Bacillus subtilis

    J Mol Biol. 2009 Mar 6;386(4):962-75. doi: 10.1016/j.jmb.2008.10.061. Epub 2008 Oct 30. PubMed PMID: 18996130.
    Wang ST, Setlow B, Conlon EM, Lyon JL, Imamura D, Sato T, Setlow P, Losick R, Eichenberger P

    The forespore line of gene expression in Bacillus subtilis

    J Mol Biol. 2006 Apr 21;358(1):16-37. Epub 2006 Feb 8. PubMed PMID: 16497325.
    Meile JC, Wu LJ, Ehrlich SD, Errington J, Noirot P

    Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory

    Proteomics. 2006 Apr;6(7):2135-46. PubMed PMID: 16479537.
    Yao F, Strauch MA

    Independent and interchangeable multimerization domains of the AbrB, Abh, and SpoVT global regulatory proteins

    J Bacteriol. 2005 Sep;187(18):6354-62. Erratum in: J Bacteriol. 2005 Nov;187(21):7546. PubMed PMID: 16159768; PubMed Central PMCID: PMC1236651.
    Söding J, Biegert A, Lupas AN

    The HHpred interactive server for protein homology detection and structure prediction

    Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W244-8. PubMed PMID: 15980461; PubMed Central PMCID: PMC1160169.
    Dong TC, Cutting SM, Lewis RJ

    DNA-binding studies on the Bacillus subtilis transcriptional regulator and AbrB homologue, SpoVT

    FEMS Microbiol Lett. 2004 Apr 15;233(2):247-56. PubMed PMID: 15063493.
    Bagyan I, Hobot J, Cutting S

    A compartmentalized regulator of developmental gene expression in Bacillus subtilis

    J Bacteriol. 1996 Aug;178(15):4500-7. PubMed PMID: 8755877; PubMed Central PMCID: PMC178216.
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