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Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, TreR regulon

The TreR regulon


  • Coordinates on the chromosome (coding sequence): 853,556 -> 854,272
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • GntR family of transcription factors
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity


  • 2OGG (effector binding domain) PubMed
  • Localization


    Additional information

    Expression and Regulation


  • treP-treA-treR PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • induced by trehalose (TreR) PubMed
  • repressed by glucose (CcpA) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed
  • Regulatory mechanism

  • TreR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • PhoP: transcription activation PubMed
  • Additional information

    Biological materials


  • MGNA-C261 (treR::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Ujiie H, Matsutani T, Tomatsu H, Fujihara A, Ushida C, Miwa Y, Fujita Y, Himeno H, Muto A

    Trans-translation is involved in the CcpA-dependent tagging and degradation of TreP in Bacillus subtilis

    J Biochem. 2009 Jan;145(1):59-66. doi: 10.1093/jb/mvn143. Epub 2008 Oct 30. PubMed PMID: 18977770.
    Rezácová P, Krejciríková V, Borek D, Moy SF, Joachimiak A, Otwinowski Z

    The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly

    Proteins. 2007 Nov 15;69(3):679-82. PubMed PMID: 17705272; PubMed Central PMCID: PMC2678876.
    Bürklen L, Schöck F, Dahl MK

    Molecular analysis of the interaction between the Bacillus subtilis trehalose repressor TreR and the tre operator

    Mol Gen Genet. 1998 Oct;260(1):48-55. PubMed PMID: 9829827.
    Schöck F, Dahl MK

    Analysis of DNA flanking the treA gene of Bacillus subtilis reveals genes encoding a putative specific enzyme IITre and a potential regulator of the trehalose operon

    Gene. 1996 Oct 10;175(1-2):59-63. PubMed PMID: 8917076.
    Schöck F, Dahl MK

    Expression of the tre operon of Bacillus subtilis 168 is regulated by the repressor TreR

    J Bacteriol. 1996 Aug;178(15):4576-81. PubMed PMID: 8755887; PubMed Central PMCID: PMC178226.
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