veg

veg
168

negative effector of [protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR] activity

locus
BSU_00440
Molecular weight
9.41 kDa
pI
4.81
Protein length
Gene length
function
control of [wiki|biofilm formation]
product
negative effector of [protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR] activity
essential
no
synonyms
veg

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4466 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
52,763 → 53,023
Phenotypes of a mutant
inactivation of the [gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg] gene suppresses the growth defect of a [gene|16E048FE5AF76CC771DEBBA8CB56B75A5414B3A2|cspB] [gene|0F89D0B03F54B283CDD99A940D43C18E6B5703BB|cspD] double mutant [pubmed|34361870]
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The protein
Catalyzed reaction/ biological activity
overexpression of [gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg] induces expression of the [gene|8C13E1EF5437DD8F9906643DEDCBB18DABE3B9E3|tapA]-[gene|09B082BF39703F0D9A5980E643175DBD59F5B228|sipW]-[gene|BF97457E986656E4A9FE7A858F5BDF1759850D5C|tasA] operon [Pubmed|23378512]
[protein|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg] may inhibit the [protein|920F91E748EE079FF864011D9052B073567C41E4|slrR]-[protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR] interaction [Pubmed|23378512]
Structure
[PDB|3FB9] (from Streptococcus pneumoniae, 34% identity)
[AF|P37466]
[wiki|Localization]
cytoplasm [pubmed|12761295]
Expression and Regulation
Operons
genes
[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]
description
[Pubmed|12761295]
regulation
constitutively expressed [Pubmed|12761295]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|12761295], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]

2024-03-11 07:04:13

ghost

44

6f1bb1005cb5aadaa9b38494716defc645e7e9d2

6DE239061A74A807BB4E807B98D4CDFF544CF7BF

Biological materials
Mutant
GP2888 (Δ[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]::ermC trpC2) available in [wiki|Jörg Stülke]'s lab [pubmed|34361870]
MGNA-B909 (veg::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1908 NBRP B. subtilis, Japan]
BKE00440 (Δ[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGCATCCACCTCACTAC,  downstream forward: _UP4_TAACGGGCAGTGAACCTTTT
BKK00440 (Δ[gene|B8BEE21D8E14F4B04B004573597EA26F5E6DAA39|veg]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTGCATCCACCTCACTAC,  downstream forward: _UP4_TAACGGGCAGTGAACCTTTT
Expression vectors
pGP3138: Constitutive overexpression, based on [wiki|pBQ200], available in [wiki|Jörg Stülke]'s lab
lacZ fusion
GP2898 ([gene|DE4857E8A228F145EFB9B7AD817585258344ED1F|amyE]::(Pveg-lacZ cat) trpC2) available in [wiki|Jörg Stülke]'s lab
References
12761295,23378512,23701187,34361870

B8BEE21D8E14F4B04B004573597EA26F5E6DAA39

Page visits: 4985

Time of last update: 2024-03-28 03:44:04

Author of last update: Jstuelk