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Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

The XylR regulon


  • Coordinates on the chromosome (coding sequence): 1,890,512 -> 1,891,564
  • The protein

    Catalyzed reaction/ biological activity

  • transcription repression of the xylA-xylB and the xynP-xynB operons
  • Protein family

  • ROK (nagC/xylR) family (according to Swiss-Prot)
  • Paralogous protein(s)

  • GlcK
  • Kinetic information




    Effectors of protein activity

  • inducer: xylose
  • Structure



    Additional information

    Expression and Regulation


  • xylR (according to DBTBS)
  • Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


  • GP270 (erm), GP1302 (aphA3), available in the Stülke lab
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein

  • Wolfgang Hillen, Erlangen University, Germany Homepage
  • References

    Commichau FM, Alzinger A, Sande R, Bretzel W, Reuß DR, Dormeyer M, Chevreux B, Schuldes J, Daniel R, Akeroyd M, Wyss M, Hohmann HP, Prágai Z

    Engineering Bacillus subtilis for the conversion of the antimetabolite 4-hydroxy-l-threonine to pyridoxine

    Metab Eng. 2015 May;29:196-207. doi: 10.1016/j.ymben.2015.03.007. Epub 2015 Mar 14. PubMed PMID: 25777134.
    Kauder C, Allmansberger R, Gärtner D, Schmiedel D, Hillen W

    An operator binding-negative mutation of Xyl repressor from Bacillus subtilis is trans dominant in Bacillus megaterium

    FEMS Microbiol Lett. 1993 May 1;109(1):81-4. PubMed PMID: 8319885.
    Dahl MK, Degenkolb J, Hillen W

    Transcription of the xyl operon is controlled in Bacillus subtilis by tandem overlapping operators spaced by four base-pairs

    J Mol Biol. 1994 Oct 28;243(3):413-24. PubMed PMID: 7966270.
    Titgemeyer F, Reizer J, Reizer A, Saier MH Jr

    Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria

    Microbiology. 1994 Sep;140 ( Pt 9):2349-54. PubMed PMID: 7952186.
    Dahl MK, Schmiedel D, Hillen W

    Glucose and glucose-6-phosphate interaction with Xyl repressor proteins from Bacillus spp

    may contribute to regulation of xylose utilization. J Bacteriol. 1995 Oct;177(19):5467-72. PubMed PMID: 7559331; PubMed Central PMCID: PMC177353.
    Kreuzer P, Gärtner D, Allmansberger R, Hillen W

    Identification and sequence analysis of the Bacillus subtilis W23 xylR gene and xyl operator

    J Bacteriol. 1989 Jul;171(7):3840-5. PubMed PMID: 2544559; PubMed Central PMCID: PMC210133.
    Gärtner D, Degenkolb J, Ripperger JA, Allmansberger R, Hillen W

    Regulation of the Bacillus subtilis W23 xylose utilization operon: interaction of the Xyl repressor with the xyl operator and the inducer xylose

    Mol Gen Genet. 1992 Apr;232(3):415-22. PubMed PMID: 1588910.
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