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Categories containing this gene/protein
utilization of specific carbon sources, transcription factors and their control
This gene is a member of the following regulons
Coordinates on the chromosome (coding sequence): 1,890,512 -> 1,891,564
Catalyzed reaction/ biological activitytranscription repression of the xylA-xylB and the xynP-xynB operons
Protein familyROK (nagC/xylR) family (according to Swiss-Prot)
Effectors of protein activityinducer: xylose
Expression and Regulation
OperonxylR (according to DBTBS)
MutantGP270 (erm), GP1302 (aphA3), available in the Stülke lab
Labs working on this gene/protein
Wolfgang Hillen, Erlangen University, Germany Homepage
Commichau FM, Alzinger A, Sande R, Bretzel W, Reuß DR, Dormeyer M, Chevreux B,
Schuldes J, Daniel R, Akeroyd M, Wyss M, Hohmann HP, Prágai Z
Bacillus subtilis for the conversion of the antimetabolite 4-hydroxy-l-threonine
to pyridoxine Metab Eng. 2015 May;29:196-207. doi: 10.1016/j.ymben.2015.03.007.
Epub 2015 Mar 14. PubMed PMID: 25777134.
Kauder C, Allmansberger R, Gärtner D, Schmiedel D, Hillen W
binding-negative mutation of Xyl repressor from Bacillus subtilis is trans
dominant in Bacillus megaterium FEMS Microbiol Lett. 1993 May 1;109(1):81-4.
PubMed PMID: 8319885.
Dahl MK, Degenkolb J, Hillen W
Transcription of the xyl operon is controlled
in Bacillus subtilis by tandem overlapping operators spaced by four base-pairs J
Mol Biol. 1994 Oct 28;243(3):413-24. PubMed PMID: 7966270.
Titgemeyer F, Reizer J, Reizer A, Saier MH Jr
between sugar kinases and transcriptional repressors in bacteria Microbiology.
1994 Sep;140 ( Pt 9):2349-54. PubMed PMID: 7952186.
Dahl MK, Schmiedel D, Hillen W
Glucose and glucose-6-phosphate interaction
with Xyl repressor proteins from Bacillus spp may contribute to regulation of
xylose utilization. J Bacteriol. 1995 Oct;177(19):5467-72. PubMed PMID: 7559331;
PubMed Central PMCID: PMC177353.
Kreuzer P, Gärtner D, Allmansberger R, Hillen W
Identification and sequence
analysis of the Bacillus subtilis W23 xylR gene and xyl operator J Bacteriol.
1989 Jul;171(7):3840-5. PubMed PMID: 2544559; PubMed Central PMCID: PMC210133.
Gärtner D, Degenkolb J, Ripperger JA, Allmansberger R, Hillen W
the Bacillus subtilis W23 xylose utilization operon: interaction of the Xyl
repressor with the xyl operator and the inducer xylose Mol Gen Genet. 1992
Apr;232(3):415-22. PubMed PMID: 1588910.