SubtiBank SubtiBank

Categories containing this gene/protein

protein modification, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigB regulon


  • Coordinates on the chromosome (coding sequence): 862,004 -> 862,474
  • The protein

    Catalyzed reaction/ biological activity

  • Protein tyrosine phosphate + H2O = protein tyrosine + phosphate (according to Swiss-Prot)
  • Protein family

  • low molecular weight phosphotyrosine protein phosphatase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • YwlE
  • Kinetic information




    Effectors of protein activity


  • 4ETM
  • Localization


    Additional information

    Expression and Regulation


  • yfkJ-yfkI-yfkH (according to DBTBS)
  • Sigma factor

  • SigA PubMed, SigB PubMed
  • Regulation

  • induced by stress (SigB) PubMed
  • Regulatory mechanism

    Additional information

    Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Reder A, Höper D, Gerth U, Hecker M

    Contributions of individual σB-dependent general stress genes to oxidative stress resistance of Bacillus subtilis

    J Bacteriol. 2012 Jul;194(14):3601-10. doi: 10.1128/JB.00528-12. Epub 2012 May 11. PubMed PMID: 22582280; PubMed Central PMCID: PMC3393503.
    Musumeci L, Bongiorni C, Tautz L, Edwards RA, Osterman A, Perego M, Mustelin T, Bottini N

    Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis

    J Bacteriol. 2005 Jul;187(14):4945-56. PubMed PMID: 15995210; PubMed Central PMCID: PMC1169535.
    Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N

    In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE

    J Bacteriol. 2005 May;187(10):3384-90. PubMed PMID: 15866923; PubMed Central PMCID: PMC1112022.
    Höper D, Völker U, Hecker M

    Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis

    J Bacteriol. 2005 Apr;187(8):2810-26. PubMed PMID: 15805528; PubMed Central PMCID: PMC1070366.
    Price CW, Fawcett P, Cérémonie H, Su N, Murphy CK, Youngman P

    Genome-wide analysis of the general stress response in Bacillus subtilis

    Mol Microbiol. 2001 Aug;41(4):757-74. PubMed PMID: 11532142.
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