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Categories containing this gene/protein

transcription, sigma factors and their control

This gene is a member of the following regulons

Spx regulon, YlaC regulon

The YlaC regulon


  • Coordinates on the chromosome (coding sequence): 1,544,085 -> 1,544,606
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • ECF subfamily (according to Swiss-Prot)
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity

  • YlaD acts as anti-sigma PubMed
  • Structure



  • YlaC-YlaD PubMed, YlaC-RpoB-RpoC
  • Additional information

    Expression and Regulation


  • ylaA-ylaB-ylaC-ylaD PubMed
  • ylaC-ylaD PubMed
  • Sigma factor

  • ylaA: YlaC PubMed
  • ylaC: SigA PubMed
  • Regulation

    Regulatory mechanism

  • Spx: transcription activation PubMed
  • Additional information

    Biological materials


  • MGNA-B356 (ylaC::erm), available at the NBRP B. subtilis, Japan
  • 1A908 ( ylaC::kan), PubMed, available at BGSC
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Souza BM(1), Castro TL(1), Carvalho RD(1), Seyffert N(1), Silva A(2), Miyoshi A(1), Azevedo V(1).

    σ(ECF) factors of gram-positive bacteria: a focus on Bacillus subtilis and the CMNR group.

    Virulence. 2014 Jul 1;5(5):587-600. doi: 10.4161/viru.29514. Epub 2014 Jun 12.

    Original publications

    Luo Y, Asai K, Sadaie Y, Helmann JD

    Transcriptomic and phenotypic characterization of a Bacillus subtilis strain without extracytoplasmic function σ factors

    J Bacteriol. 2010 Nov;192(21):5736-45. doi: 10.1128/JB.00826-10. Epub 2010 Sep 3. PubMed PMID: 20817771; PubMed Central PMCID: PMC2953670.
    Mascher T, Hachmann AB, Helmann JD

    Regulatory overlap and functional redundancy among Bacillus subtilis extracytoplasmic function sigma factors

    J Bacteriol. 2007 Oct;189(19):6919-27. Epub 2007 Aug 3. PubMed PMID: 17675383; PubMed Central PMCID: PMC2045236.
    Ryu HB, Shin I, Yim HS, Kang SO

    YlaC is an extracytoplasmic function (ECF) sigma factor contributing to hydrogen peroxide resistance in Bacillus subtilis

    J Microbiol. 2006 Apr;44(2):206-16. PubMed PMID: 16728958.
    Matsumoto T, Nakanishi K, Asai K, Sadaie Y

    Transcriptional analysis of the ylaABCD operon of Bacillus subtilis encoding a sigma factor of extracytoplasmic function family

    Genes Genet Syst. 2005 Dec;80(6):385-93. PubMed PMID: 16501307.
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