It will happen very soon:
International Conference on Bacilli and Gram-positive bacteria
June 11 - 15, 2017, Berlin, Germany
Check out the program here
Dear users of SubtiWiki,
We have scheduled the server update on Sunday, 28th May, 2017. The website might be unreachable for a few hours. We appologize for the inconvinience and thank you for your understanding.
We will also use the time to upgrade SubtiWiki to a new version. It is current avaible online. Have a preview at Here
In the coming Bacilli meeting in Berlin, we will be hosting a SubtiWiki workshop, where we will reveal all nnew features as well as the strategies used behind the scene. We sincerely welcomme you to join.
Thank you for your understanding and support.
Your SubtiWiki Team
Categories containing this gene/protein
transcription, sigma factors and their control
This gene is a member of the following regulons
Spx regulon, YlaC regulon
Coordinates on the chromosome (coding sequence): 1,544,085 -> 1,544,606
Catalyzed reaction/ biological activity
Protein familyECF subfamily (according to Swiss-Prot)
Effectors of protein activityYlaD acts as anti-sigma PubMed
StructureYlaC-YlaD PubMed, YlaC-RpoB-RpoC
Expression and Regulation
OperonylaA-ylaB-ylaC-ylaD PubMedylaC-ylaD PubMedylaA: YlaC PubMedylaC: SigA PubMed
Regulatory mechanismSpx: transcription activation PubMed
MutantMGNA-B356 (ylaC::erm), available at the NBRP B. subtilis, Japan1A908 ( ylaC::kan), PubMed, available at BGSC
Labs working on this gene/protein
Souza BM(1), Castro TL(1), Carvalho RD(1), Seyffert N(1), Silva A(2), Miyoshi
A(1), Azevedo V(1).
σ(ECF) factors of gram-positive bacteria: a focus on Bacillus subtilis and the
CMNR group. Virulence. 2014 Jul 1;5(5):587-600. doi: 10.4161/viru.29514. Epub 2014 Jun 12.
Luo Y, Asai K, Sadaie Y, Helmann JD
Transcriptomic and phenotypic
characterization of a Bacillus subtilis strain without extracytoplasmic function
σ factors J Bacteriol. 2010 Nov;192(21):5736-45. doi: 10.1128/JB.00826-10. Epub
2010 Sep 3. PubMed PMID: 20817771; PubMed Central PMCID: PMC2953670.
Mascher T, Hachmann AB, Helmann JD
Regulatory overlap and functional
redundancy among Bacillus subtilis extracytoplasmic function sigma factors J
Bacteriol. 2007 Oct;189(19):6919-27. Epub 2007 Aug 3. PubMed PMID: 17675383;
PubMed Central PMCID: PMC2045236.
Ryu HB, Shin I, Yim HS, Kang SO
YlaC is an extracytoplasmic function (ECF)
sigma factor contributing to hydrogen peroxide resistance in Bacillus subtilis J
Microbiol. 2006 Apr;44(2):206-16. PubMed PMID: 16728958.
Matsumoto T, Nakanishi K, Asai K, Sadaie Y
Transcriptional analysis of the
ylaABCD operon of Bacillus subtilis encoding a sigma factor of extracytoplasmic
function family Genes Genet Syst. 2005 Dec;80(6):385-93. PubMed PMID: 16501307.