SubtiBank SubtiBank

Categories containing this gene/protein

transporters/ other, putative amino acid transporter, membrane proteins

This gene is a member of the following regulons

TnrA regulon


  • Coordinates on the chromosome (coding sequence): 2,130,377 -> 2,131,867
  • The protein

    Catalyzed reaction/ biological activity

  • in some database, the protein is annotated as being similar to proline permease, however, it is not involved in proline transport PubMed
  • Protein family

  • solute:sodium symporter family (SSS family)
  • Paralogous protein(s)

  • YhjB
  • Kinetic information




    Effectors of protein activity



  • membrane PubMed
  • Interactions

    Additional information

    Expression and Regulation


  • yoyD-yodF PubMed
  • Sigma factor


  • repressed by casamino acids PubMed
  • repressed in the absence of good nitrogen sources (glutamine or ammonium) (TnrA) PubMed
  • Regulatory mechanism

  • TnrA: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-B437 (yodF::erm), available at the NBRP B. subtilis, Japan
  • available in Erhard Bremer's lab PubMed
  • GP1887 (kan) available in Jörg Stülke's lab
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Mirouze N, Bidnenko E, Noirot P, Auger S

    Genome-wide mapping of TnrA-binding sites provides new insights into the TnrA regulon in Bacillus subtilis

    Microbiologyopen. 2015 Jun;4(3):423-35. doi: 10.1002/mbo3.249. PubMed PMID: 25755103; PubMed Central PMCID: PMC4475385.
    Zaprasis A, Hoffmann T, Stannek L, Gunka K, Commichau FM, Bremer E

    The γ-aminobutyrate permease GabP serves as the third proline transporter of Bacillus subtilis

    J Bacteriol. 2014 Feb;196(3):515-26. doi: 10.1128/JB.01128-13. PubMed PMID: 24142252; PubMed Central PMCID: PMC3911147.
    Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P

    Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis

    Science. 2012 Mar 2;335(6072):1103-6. doi: 10.1126/science.1206848. PubMed PMID: 22383849.
    Hahne H, Wolff S, Hecker M, Becher D

    From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches

    Proteomics. 2008 Oct;8(19):4123-36. doi: 10.1002/pmic.200800258. PubMed PMID: 18763711.
    Yoshida K, Yamaguchi H, Kinehara M, Ohki YH, Nakaura Y, Fujita Y

    Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box

    Mol Microbiol. 2003 Jul;49(1):157-65. PubMed PMID: 12823818.
    Mäder U, Homuth G, Scharf C, Büttner K, Bode R, Hecker M

    Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability

    J Bacteriol. 2002 Aug;184(15):4288-95. PubMed PMID: 12107147; PubMed Central PMCID: PMC135197.
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