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Categories containing this gene/protein

transcription factors and their control, cold stress proteins, resistance against toxins/ antibiotics

This gene is a member of the following regulons

YtrA regulon

The YtrA regulon


  • Coordinates on the chromosome (coding sequence): 3,118,847 -> 3,119,239
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • GntR family of transcription factors
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity


  • 3NEU (similar protein from Listeria innocua, 41% identity)
  • Localization


    Additional information

    Expression and Regulation


  • ytrG-ytrA-ytrB-ytrC-ytrD-ytrE-ytrF PubMed
  • Sigma factor

  • SigA PubMed
  • Regulation

  • induced by ramoplanin (YtrA) PubMed
  • expressed early in the stationary phase PubMed
  • induced by cold shock (5-fold) PubMed
  • Regulatory mechanism

  • YtrA: transcription repression PubMed
  • Additional information

    Biological materials


  • MGNA-A138 (ytrA::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Leyn SA, Kazanov MD, Sernova NV, Ermakova EO, Novichkov PS, Rodionov DA

    Genomic reconstruction of the transcriptional regulatory network in Bacillus subtilis

    J Bacteriol. 2013 Jun;195(11):2463-73. doi: 10.1128/JB.00140-13. Epub 2013 Mar 15. PubMed PMID: 23504016; PubMed Central PMCID: PMC3676070.
    Salzberg LI, Luo Y, Hachmann AB, Mascher T, Helmann JD

    The Bacillus subtilis GntR family repressor YtrA responds to cell wall antibiotics

    J Bacteriol. 2011 Oct;193(20):5793-801. doi: 10.1128/JB.05862-11. Epub 2011 Aug 19. PubMed PMID: 21856850; PubMed Central PMCID: PMC3187214.
    Beckering CL, Steil L, Weber MH, Völker U, Marahiel MA

    Genomewide transcriptional analysis of the cold shock response in Bacillus subtilis

    J Bacteriol. 2002 Nov;184(22):6395-402. PubMed PMID: 12399512; PubMed Central PMCID: PMC151959.
    Yoshida KI, Fujita Y, Ehrlich SD

    An operon for a putative ATP-binding cassette transport system involved in acetoin utilization of Bacillus subtilis

    J Bacteriol. 2000 Oct;182(19):5454-61. PubMed PMID: 10986249; PubMed Central PMCID: PMC110989.
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