SubtiBank SubtiBank

Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons


  • Coordinates on the chromosome (coding sequence): 3,222,195 -> 3,223,367
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • iron-containing alcohol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s)

  • YugJ
  • Kinetic information




    Effectors of protein activity




    Additional information

    Expression and Regulation


  • yugK PubMed
  • Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-B548 (yugK::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Jarboe LR(1).

    YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals.

    Appl Microbiol Biotechnol. 2011 Jan;89(2):249-57. doi: 10.1007/s00253-010-2912-9. Epub 2010 Oct 6.

    Original publications

    Oudega B(1), Koningstein G, Rodrigues L, de Sales Ramon M, Hilbert H, Düsterhöft A, Pohl TM, Weitzenegger T.

    Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).

    Microbiology. 1997 Aug;143 ( Pt 8):2769-74.

    The corresponding protein in E. coli

    Lee C, Kim I, Lee J, Lee KL, Min B, Park C

    Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12

    J Bacteriol. 2010 Aug;192(16):4205-14. doi: 10.1128/JB.01127-09. PubMed PMID: 20543070; PubMed Central PMCID: PMC2916428.
    Pérez JM, Arenas FA, Pradenas GA, Sandoval JM, Vásquez CC

    Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes

    J Biol Chem. 2008 Mar 21;283(12):7346-53. doi: 10.1074/jbc.M708846200. PubMed PMID: 18211903.
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