SubtiBank SubtiBank

Categories containing this gene/protein

ABC transporters, utilization of specific carbon sources, utilization of nitrogen sources other than amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon


  • Coordinates on the chromosome (coding sequence): 3,345,013 -> 3,346,116
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

    Paralogous protein(s)

    Kinetic information



  • phosphorylated on Ser-3 PubMed
  • Cofactors

    Effectors of protein activity



  • membrane associated (via FrlM-FrlN) PubMed
  • Interactions

  • YurJ-(FrlM-FrlN)-FrlO PubMed
  • Additional information

    Expression and Regulation


    Sigma factor


  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism

  • CodY: transcription repression PubMed
  • Additional information

    Biological materials


    Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Soufi B, Kumar C, Gnad F, Mann M, Mijakovic I, Macek B

    Stable isotope labeling by amino acids in cell culture (SILAC) applied to quantitative proteomics of Bacillus subtilis

    J Proteome Res. 2010 Jul 2;9(7):3638-46. doi: 10.1021/pr100150w. PubMed PMID: 20509597.
    Hahne H, Wolff S, Hecker M, Becher D

    From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches

    Proteomics. 2008 Oct;8(19):4123-36. doi: 10.1002/pmic.200800258. PubMed PMID: 18763711.
    Molle V, Nakaura Y, Shivers RP, Yamaguchi H, Losick R, Fujita Y, Sonenshein AL

    Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis

    J Bacteriol. 2003 Mar;185(6):1911-22. PubMed PMID: 12618455; PubMed Central PMCID: PMC150151.
    Quentin Y, Fichant G, Denizot F

    Inventory, assembly and analysis of Bacillus subtilis ABC transport systems

    J Mol Biol. 1999 Apr 2;287(3):467-84. PubMed PMID: 10092453.
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