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Categories containing this gene/protein

transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

The YvrHb regulon


  • Coordinates on the chromosome (coding sequence): 3,408,353 -> 3,409,066
  • Phenotypes of a mutant

  • unusual autolysis and higher susceptibility to cell envelope antibiotics (bacitracin, aztreonam, cefepime, fosfomycin) PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • transcription activator PubMed
  • Protein family

  • OmpR family of two-component response regulators
  • Paralogous protein(s)

    Kinetic information



  • phosphorylation (Asp) by YvrG PubMed
  • Cofactors

    Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity
  • Structure


  • cytoplasm (according to Swiss-Prot)
  • Interactions

  • YvrG-YvrHb PubMed
  • Additional information

    Expression and Regulation


    Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-B050 (yvrH::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Salzberg LI, Helmann JD

    Phenotypic and transcriptomic characterization of Bacillus subtilis mutants with grossly altered membrane composition

    J Bacteriol. 2008 Dec;190(23):7797-807. doi: 10.1128/JB.00720-08. Epub 2008 Sep 26. PubMed PMID: 18820022; PubMed Central PMCID: PMC2583605.
    Serizawa M, Kodama K, Yamamoto H, Kobayashi K, Ogasawara N, Sekiguchi J

    Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses

    Biosci Biotechnol Biochem. 2005 Nov;69(11):2155-69. PubMed PMID: 16306698.
    Fabret C, Feher VA, Hoch JA

    Two-component signal transduction in Bacillus subtilis: how one organism sees its world

    J Bacteriol. 1999 Apr;181(7):1975-83. Review. PubMed PMID: 10094672; PubMed Central PMCID: PMC93607.
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