SubtiBank SubtiBank

Categories containing this gene/protein

transcription factors and their control, biofilm formation

This gene is a member of the following regulons

The YwcC regulon


  • Coordinates on the chromosome (coding sequence): 3,922,292 -> 3,922,963
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • TetR family
  • Paralogous protein(s)

    Kinetic information




    Effectors of protein activity




    Additional information

    Expression and Regulation


  • ywcC-gtcA-galK-galT PubMed
  • Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-B230 (ywcC::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein



    Cuthbertson L(1), Nodwell JR.

    The TetR family of regulators.

    Microbiol Mol Biol Rev. 2013 Sep;77(3):440-75. doi: 10.1128/MMBR.00018-13.

    Original publications

    Yu Y, Yan F, Chen Y, Jin C, Guo JH, Chai Y

    Poly-γ-Glutamic Acids Contribute to Biofilm Formation and Plant Root Colonization in Selected Environmental Isolates of Bacillus subtilis

    Front Microbiol. 2016 Nov 10;7:1811. PubMed PMID: 27891125; PubMed Central PMCID: PMC5102903.
    Chai Y, Beauregard PB, Vlamakis H, Losick R, Kolter R

    Galactose metabolism plays a crucial role in biofilm formation by Bacillus subtilis

    MBio. 2012 Aug 14;3(4):e00184-12. doi: 10.1128/mBio.00184-12. Erratum in: MBio. 2013;4(1). doi:10.1128/mBio.00555-12. PubMed PMID: 22893383; PubMed Central PMCID: PMC3419520.
    Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P

    Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis

    Science. 2012 Mar 2;335(6072):1103-6. doi: 10.1126/science.1206848. PubMed PMID: 22383849.
    Chai Y, Kolter R, Losick R

    Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis

    Mol Microbiol. 2009 Nov;74(4):876-87. doi: 10.1111/j.1365-2958.2009.06900.x. PubMed PMID: 19788541; PubMed Central PMCID: PMC2805041.
    Kobayashi K

    SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis

    Mol Microbiol. 2008 Sep;69(6):1399-410. doi: 10.1111/j.1365-2958.2008.06369.x. PubMed PMID: 18647168.
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