SubtiBank SubtiBank

It will happen very soon:

International Conference on Bacilli and Gram-positive bacteria

June 11 - 15, 2017, Berlin, Germany

Check out the program here


Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics, phosphoproteins

This gene is a member of the following regulons

The YxdJ regulon


  • Coordinates on the chromosome (coding sequence): 4,072,284 -> 4,072,973
  • The protein

    Catalyzed reaction/ biological activity

    Protein family

  • OmpR family of two-component response regulators
  • Paralogous protein(s)

    Kinetic information



  • phosphorylated by YxdK on an Asp residue
  • Cofactors

    Effectors of protein activity




    Additional information

    Expression and Regulation


  • yxdJ-yxdK PubMed
  • Sigma factor


    Regulatory mechanism

    Additional information

    Biological materials


  • MGNA-B702 (yxdJ::erm), available at the NBRP B. subtilis, Japan
  • Expression vector

    lacZ fusion

    GFP fusion

    two-hybrid system

    FLAG-tag construct


    Labs working on this gene/protein


    Leyn SA, Kazanov MD, Sernova NV, Ermakova EO, Novichkov PS, Rodionov DA

    Genomic reconstruction of the transcriptional regulatory network in Bacillus subtilis

    J Bacteriol. 2013 Jun;195(11):2463-73. doi: 10.1128/JB.00140-13. Epub 2013 Mar 15. PubMed PMID: 23504016; PubMed Central PMCID: PMC3676070.
    Coumes-Florens S, Brochier-Armanet C, Guiseppi A, Denizot F, Foglino M

    A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system

    PLoS One. 2011 Jan 19;6(1):e15951. doi: 10.1371/journal.pone.0015951. PubMed PMID: 21283517; PubMed Central PMCID: PMC3023708.
    Staroń A, Finkeisen DE, Mascher T

    Peptide antibiotic sensing and detoxification modules of Bacillus subtilis

    Antimicrob Agents Chemother. 2011 Feb;55(2):515-25. doi: 10.1128/AAC.00352-10. Epub 2010 Nov 15. PubMed PMID: 21078927; PubMed Central PMCID: PMC3028804.
    Hyyryläinen HL, Pietiäinen M, Lundén T, Ekman A, Gardemeister M, Murtomäki-Repo S, Antelmann H, Hecker M, Valmu L, Sarvas M, Kontinen VP

    The density of negative charge in the cell wall influences two-component signal transduction in Bacillus subtilis

    Microbiology. 2007 Jul;153(Pt 7):2126-36. PubMed PMID: 17600057.
    Joseph P, Guiseppi A, Sorokin A, Denizot F

    Characterization of the Bacillus subtilis YxdJ response regulator as the inducer of expression for the cognate ABC transporter YxdLM

    Microbiology. 2004 Aug;150(Pt 8):2609-17. PubMed PMID: 15289557.
    Yoshida K, Ishio I, Nagakawa E, Yamamoto Y, Yamamoto M, Fujita Y

    Systematic study of gene expression and transcription organization in the gntZ-ywaA region of the Bacillus subtilis genome

    Microbiology. 2000 Mar;146 ( Pt 3):573-9. PubMed PMID: 10746760.
    Fabret C, Feher VA, Hoch JA

    Two-component signal transduction in Bacillus subtilis: how one organism sees its world

    J Bacteriol. 1999 Apr;181(7):1975-83. Review. PubMed PMID: 10094672; PubMed Central PMCID: PMC93607.
    No login